Gut-Induced Alpha-Synuclein and Tau Propagation Initiate Parkinson’s and Alzheimer’s Disease Co-Pathology and Behavior Impairments

Medicine, Neurology, Gastroenterology, Medical Imaging, Life Sciences, Cell Biology,
alpha-synuclein   tau protein   Parkinson's disease   Alzheimer's disease   behavioral impairments   gut-brain axis   neurodegeneration  

Gastrointestinal-Induced Spread of α-Synuclein and Tau Proteins Triggers Comorbid Pathology and Behavioral Impairments in Parkinson’s and Alzheimer’s Diseases Background Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are two common neurodegenerative disorders, caused by the aggregation of α-synuclein (a-syn) and Tau protein in the brain, res...

Ferroptosis Triggered by Spliceosomal GTPase EFTUD2 Deficiency Leads to Purkinje Cell Degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
spliceosome   EFTUD2   ferroptosis   Purkinje cells   neurodegeneration   cerebellar development  

Depletion of EFTUD2 Triggers Ferroptosis-Induced Degeneration of Cerebellar Purkinje Cells Background and Motivation The cerebellum plays a crucial role in motor coordination and higher cognitive functions, with the health of cerebellar Purkinje cells (PCs) being essential for maintaining cerebellar function. Gene regulation based on alternative sp...

Disruption of Nuclear Speckle Integrity Dysregulates RNA Splicing in C9orf72-FTD/ALS

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
nuclear speckles   RNA splicing   C9orf72   FTD   ALS  

Disruption of Nucleolar Integrity and Dysregulation of RNA Splicing in C9orf72-FTD/ALS Background and Research Motivation The hexanucleotide repeat expansion (GGGGCC)n in the C9orf72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Studies have shown that these repeat sequences not only...

The Role of Motor Cortex in Striatal Motor Dynamics and Execution of Skilled and Unskilled Actions

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology,
motor cortex   striatal dynamics   action execution   neuroscience   lesions  

Exploring the Crucial Role of the Motor Cortex in Basal Ganglia and Dynamic Motor Control Research Background and Motivation The role of the motor cortex (Motor Cortex, M1) in motor generation and regulation has long been a significant topic in neuroscience. The interaction between M1 and the striatum in selecting and executing goal-directed action...

Flexible Control of Sequence Working Memory in the Macaque Frontal Cortex

Medicine, Neurology, Life Sciences, Biophysics,
flexible control   sequence working memory   neural subspaces   macaques   frontal cortex  

Research Background In our daily lives, Sequence Working Memory (SWM) is crucial; for example, when filling in a birth date, the year, month, and day need to be recalled and arranged in a specific order. However, how the brain controls information in sequential memory and flexibly orders information under different task demands remains an unsolved ...

Molecular and Circuit Determinants in the Globus Pallidus Mediating Control of Cocaine-Induced Behavioral Plasticity

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry,
globus pallidus   cocaine   behavioral plasticity   circuit regulation   potassium channels   carnosic acid  

Scientific News Report: The Molecular and Neural Circuit Mechanisms in the Globus Pallidus for Controlling Cocaine-Induced Behavioral Plasticity In the field of the neurobiology of drug abuse, this paper provides a new perspective for exploring cocaine-induced behavioral plasticity and neural circuit regulation. The research team centered on the Gl...