IL-22 Restores Gut Homeostasis and Alleviates Diet-Induced MASLD In recent years, the incidence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has significantly increased, closely related to the widespread consumption of high-energy diets rich in sugars and fats. MASLD is not only closely linked to metabolic diseases such as ob...

Comprehensive Clinical and Preclinical Studies Reveal the Therapeutic Potential of Ferroterminator1 (FOT1) for Metabolic-Associated Fatty Liver Disease (MAFLD) Background: Research Needs on MAFLD and Iron Overload Issues Metabolic-associated fatty liver disease (MAFLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a common chroni...

Fusobacterium nucleatum Promotes Anti-PD-1 Therapy in Microsatellite-Stable Colorectal Cancer Background Introduction With the rise of immune checkpoint blockade (ICB) therapy, a new dawn has emerged in cancer treatment. However, despite the approval of PD-1 targeting drugs (e.g., Pembrolizumab) for certain types of colorectal cancer (CRC) patients...

The Role of Neoadjuvant Chemoradiotherapy Combined or Not Combined with PD-1 Antibody Sintilimab in pMMR Locally Advanced Rectal Cancer: Results of a Randomized Clinical Trial Background and Significance The management of rectal cancer and organ preservation has always been quite challenging, especially in cases of locally advanced rectal cancer (L...

Progress in Cancer Research: Inhibitory Mechanisms and Effects of Erianin on Pancreatic Cancer Background and Significance of the Study Pancreatic cancer is a malignant tumor of the digestive tract, characterized by inconspicuous early symptoms, high malignancy, and limited efficacy of conventional radiotherapy and chemotherapy, leading to a very h...