Aβ-Aggregation-Generated Blue Autofluorescence Illuminates Senile Plaques as Well as Complex Blood and Vascular Pathologies in Alzheimer’s Disease

Medicine, Neurology, Hematology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry,
Senile plaque   Blue autofluorescence   Aβ   Amyloid aggregation   Hemoglobin   Cathepsin D   Microaneurysm   Alzheimer's disease  

Blue Autofluorescence Generated by Aβ Aggregation Illuminates Senile Plaques and Complex Blood and Vascular Pathologies in Alzheimer’s Disease Research Background Alzheimer’s disease (AD) is a widespread neurodegenerative disorder globally, with senile plaques being the main pathological hallmark of AD, primarily composed of β-amyloid protein (Aβ)....

4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20

Medicine, Rheumatology and Immunology, Hematology, Life Sciences, Immunology,
chimeric antigen receptor   CAR-T cell   4-1BB   apoptosis   necroptosis   A20   NF-κB  

Background Introduction Chimeric antigen receptor T cells (CAR-T cells) have shown great potential in immunotherapy for certain hematological malignancies. However, how the CD28 and 4-1BB costimulatory domains included in CAR molecules function in CAR-T cells is still not fully understood. Both CD28 and 4-1BB domains exhibit significantly different...

Synergy of TL1A and IL-18 promotes GM-CSF-dependent thymic granulopoiesis in mice

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Hematology, Life Sciences, Immunology,
TL1A   IL-18   thymic neutrophils   acute thymic atrophy   cytokine synergy   extramedullary granulopoiesis  

Background Introduction In acute systemic inflammatory conditions, the immune system undergoes significant changes, typically characterized by increased myeloid cell generation and suppressed lymphocyte production. In the thymus specifically, systemic inflammation leads to acute thymic atrophy and subsequent impairment of T lymphocyte generation. H...

Astrocytic Stress Response Induced by Exposure to Astrocyte-Binding Antibodies in Pediatric Acute Transverse Myelitis Cases

Medicine, Pediatrics, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Immunology,
Pediatric   Acute Transverse Myelitis   Astrocytes   Antibodies   Neuroinflammation  

B-cell Response in Pediatric Acute Transverse Myelitis Acute transverse myelitis (ATM) is an autoimmune-mediated inflammatory disease of the spinal cord with an incidence of 1.7-2 cases per million children per year. ATM typically presents with limb weakness, sensory loss, and bladder/bowel dysfunction, with symptoms rapidly developing over hours t...

Single-Cell RNA Sequencing Reveals the Evolution of the Immune Landscape During Perihematomal Edema Progression After Intracerebral Hemorrhage

Medicine, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
intracerebral hemorrhage   single cell RNA sequencing   perihematomal edema   immune cell   osteopontin  

Single-cell RNA Sequencing Reveals Evolution of Immune Landscape in Perihematomal Edema Post Hemorrhagic Stroke Research Background Intracerebral hemorrhage (ICH) is one of the global health threats, renowned for its high disability and mortality rates. Among the secondary brain injuries caused by ICH, the formation of perihematomal edema (PHE) is ...

Quantitative Integrative Survival Prediction in Multiple Myeloma Patients

Medicine, Basic Medical Sciences, Hematology, Oncology,
Multiple Myeloma   Survival Prediction   Quantitative Model   Molecular Prognostic Factors   Continuous Risk Assessment  

Precision Medicine | Quantitative Comprehensive Survival Prediction for Patients with Multiple Myeloma: Based on Bortezomib Induction Therapy, High-Dose Treatment, and Autologous Stem Cell Transplantation Introduction Multiple myeloma is a malignant hematological disease characterized by the accumulation of clonal plasma cells within the bone marro...