A Large Prospective Cohort Study in the United States Reveals Potential Links Between Outdoor Air Pollution and Subtypes of Adult Hematologic Cancers Background and Purpose In recent years, the impact of outdoor air pollution on human health has garnered extensive attention. Since 2013, the International Agency for Research on Cancer (IARC) has cla...
Introduction In the process of healthy hematopoiesis, a group of hematopoietic stem cells (HSC) contribute to all blood-related lineages. However, as we age, this process often leads to clonal hematopoiesis (CH), meaning the expansion of clones originating from a particular HSC, which then occupies a significant portion of blood cells and platelets...
This is an academic paper report on the study of acute myeloid leukemia (AML) stem cells. The study found that venetoclax treatment targeting the BCL-2 protein induces different mitochondrial calcium signaling changes in drug-sensitive and drug-resistant AML stem cells, thereby affecting their oxidative phosphorylation metabolism and survival. The ...
Generation of Clinically Applicable CAR-NKT Cells Research Background Chimeric Antigen Receptor (CAR) T cell therapy has been approved by the Food and Drug Administration (FDA) for the treatment of B-cell malignancies and multiple myeloma. However, the use of autologous CAR-T cell products presents challenges such as high costs, long manufacturing ...
Research Background γδ T cells play an important role in the immune system, particularly in protective immunity, homeostasis, and tissue repair. Unlike conventional αβ T cells, which are restricted by major histocompatibility complex (MHC), γδ T cells directly seed peripheral tissues and respond to various microbial stimuli without relying on MHC-p...
Gastrointestinal Infections and Gastrointestinal Bleeding in CAR-T Cell Recipients are Underrated but Severe Adverse Events: A Real-World Study Introduction In recent years, Chimeric Antigen Receptor T-cell (CAR-T) therapy has shown lasting efficacy in treating patients with hematologic malignancies. However, multi-system toxic reactions associated...