In Vivo Bruton's Tyrosine Kinase Inhibition Attenuates Alcohol-Associated Liver Disease by Regulating CD84-Mediated Granulopoiesis

Medicine, Infectious Diseases, Hepatobiliary System, Gastroenterology, Hematology, Life Sciences, Biochemistry, Immunology,
Bruton's Tyrosine Kinase   Alcohol-Associated Liver Disease   Granulopoiesis   Neutrophils   Liver Damage   Therapeutic Target  

Research Background Severe alcoholic hepatitis (ALD) is a fatal form of alcohol-associated liver disease (AALD). The course of ALD is usually accompanied by neutrophil infiltration in the liver, which significantly affects the severity of the condition. However, the specific effects of alcohol on neutrophil function remain unclear. Based on this, i...

Superior Fidelity and Distinct Editing Outcomes of SaCas9 Compared with SpCas9 in Genome Editing

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
genome editing   sacas9   spcas9   PAM sequence   insertion efficiency   off-target effects  

Comparison of SaCas9 and SpCas9 in High-Fidelity and Different Gene Editing Outcomes Research Background CRISPR systems based on Cas9 protein have become powerful tools for genome editing, widely used in basic research and clinical gene therapy. Currently, the most commonly used Cas9 variants are SpCas9 from Streptococcus pyogenes and SaCas9 from S...

Comprehensive Characterization and Global Transcriptome Analysis of Human Fetal Liver Terminal Erythropoiesis

Medicine, Hepatobiliary System, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
human fetal liver   terminal erythropoiesis   transcriptome   immortalized erythroid cell line   enucleation  

Comprehensive Characterization and Transcriptome Analysis of Terminal Erythropoiesis in Human Fetal Liver Background and Research Question Erythropoiesis is the process of red blood cell production. Initially, “primitive” erythropoiesis occurs in the yolk sac, gradually replaced by “terminal” erythropoiesis in the fetal liver (FL) and postnatal bon...

Timing of Anticoagulation Resumption and Risk of Ischemic and Hemorrhagic Complications in Patients with Intracranial Hemorrhage and Mechanical Heart Valves

Medicine, Neurology, Neurosurgery, Hematology, Cardiovascular System,
Anticoagulation   Ischemic Complications   Hemorrhagic Complications   Mechanical Heart Valves   Intracranial Hemorrhage  

Exploration of Anticoagulation Therapy Resumption Time After ICH in Mechanical Heart Valve Patients Background and Motivation For patients with mechanical heart valves, determining the appropriate time to resume oral anticoagulation therapy after experiencing an intracerebral hemorrhage (ICH) remains a significant clinical challenge. These patients...

Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection's Pathogenesis

Medicine, Infectious Diseases, Neurology, Hematology, Life Sciences, Cell Biology, Immunology,
Japanese encephalitis virus infection   hepcidin   transferrin   transferrin receptors   IL-6  

Elevated IL-6 Levels and Upregulation of Iron-Regulatory Biomarkers Promote Japanese Encephalitis Virus Infection In this research paper, the authors explore changes in inflammatory response and iron-regulatory biomarkers during Japanese Encephalitis Virus (JEV) infection. A comprehensive analysis of iron-regulatory biomarkers and inflammatory resp...

Aβ-Aggregation-Generated Blue Autofluorescence Illuminates Senile Plaques as Well as Complex Blood and Vascular Pathologies in Alzheimer’s Disease

Medicine, Neurology, Hematology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry,
Senile plaque   Blue autofluorescence   Aβ   Amyloid aggregation   Hemoglobin   Cathepsin D   Microaneurysm   Alzheimer's disease  

Blue Autofluorescence Generated by Aβ Aggregation Illuminates Senile Plaques and Complex Blood and Vascular Pathologies in Alzheimer’s Disease Research Background Alzheimer’s disease (AD) is a widespread neurodegenerative disorder globally, with senile plaques being the main pathological hallmark of AD, primarily composed of β-amyloid protein (Aβ)....