Revumenib Revises the Treatment Landscape for KMT2A-R Leukemia

Medicine, Hematology, Oncology,
Revumenib   KMT2A-R leukemia   menin inhibitors   gene expression   clinical trial   leukemia cell differentiation   drug resistance  

Revumenib Alters the Treatment Landscape for KMT2A-Rearranged Leukemia Academic Background Leukemia is a malignant disease caused by abnormalities in the hematopoietic system, with KMT2A-rearranged (KMT2A-r) leukemia being a common subtype, particularly in pediatric and adult acute myeloid leukemia (AML). Rearrangements of the KMT2A gene (lysine me...

Inotuzumab Ozogamicin and Low-Intensity Chemotherapy in Older Patients with Newly Diagnosed CD22+ Philadelphia Chromosome–Negative B-Cell Precursor Acute Lymphoblastic Leukemia

Medicine, Hematology, Oncology,
Inotuzumab Ozogamicin   Low-Intensity Chemotherapy   Acute Lymphoblastic Leukemia   Older Patients   CD22 Positive   Philadelphia Chromosome Negative   B-Cell Precursor  

Academic Background and Problem Acute lymphoblastic leukemia (ALL) is a malignant hematologic disease, particularly challenging to treat in older patients, with limited treatment options and poor outcomes. Traditional chemotherapy regimens yield long-term survival rates of only 20%-30% in elderly patients. Therefore, finding more effective and bett...

Multiomic Analysis Identifies Survival Predictors in African American Patients with Acute Myeloid Leukemia

Medicine, Medical Laboratory Science, Hematology, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
acute myeloid leukemia   African American   gene mutations   inflammation   survival predictors   genomic analysis   multiomic study  

Multi-omics Analysis Reveals Predictors of Survival in African American AML Patients Background and Objectives Acute Myeloid Leukemia (AML) is a hematologic malignancy characterized by clonal expansion of myeloid progenitor cells driven by genomic alterations. Despite advances in genomic profiling, studies focusing on diverse ancestral populations ...

Selective Advantage of Mutant Stem Cells in Human Clonal Hematopoiesis Associated with Attenuated Response to Inflammation and Aging

Medicine, Hematology, Life Sciences, Biochemistry, Immunology, Genetics,
mutant stem cells   clonal hematopoiesis   inflammation   aging   selective advantage   DNMT3A mutation   TET2 mutation  

Selective Advantage of Clonal Hematopoietic Mutant Stem Cells in Aging and Inflammatory Responses Background and Research Motivation Clonal Hematopoiesis (CH) is an aging-related phenomenon in the hematopoietic system, where hematopoietic stem cells (HSCs) acquire specific somatic mutations and undergo expansion, causing a particular mutated cell l...

Epitope Editing Protects Hematopoietic Cells from CD123 Immunotherapy for Acute Myeloid Leukemia

Medicine, Hematology, Oncology, Life Sciences, Bioengineering, Immunology, Genetics,
epitope editing   CD123   immunotherapy   acute myeloid leukemia   hematopoietic stem cells   CAR-T  

Epitope Prime Editing Shields Hematopoietic Cells from CD123 Immunotherapy: A Novel Therapeutic Strategy for Acute Myeloid Leukemia Research Background and Problem Statement Acute Myeloid Leukemia (AML) is a malignant blood disease characterized by the abnormal differentiation of myeloid hematopoietic stem and progenitor cells (HSPCs). Its incidenc...

A Distinct Metabolic and Epigenetic State Drives Trained Immunity in HSC-Derived Macrophages from Autoimmune Mice

Medicine, Rheumatology and Immunology, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
trained immunity   HSC   autoimmune   metabolic state   epigenetic  

Metabolic and Epigenetic States of HSC-Derived Macrophages in Autoimmune Diseases and Their Driving Mechanism of Trained Immunity Research Background In the context of autoimmune diseases (AD), studies have shown that prolonged activation of the immune system and inflammatory responses affect not only mature immune cells but also have profound effe...