Academic Background Protein homeostasis (proteostasis) is a core mechanism for maintaining normal cellular function, with the ubiquitin-proteasome system (UPS) responsible for degrading approximately 80% of abnormal proteins. Traditionally, proteins were thought to require ubiquitination for recognition and degradation by the 26S proteasome. Howeve...

Academic Background G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in the human body, transmitting extracellular signals through heterotrimeric G proteins (composed of Gα and Gβγ subunits). G proteins function as molecular switches, with their activity states regulated by the GTP/GDP cycle: - Inactive state: Gα bind...

1. Research Background Meiosis is the core process of sexual reproduction in eukaryotes, generating haploid gametes through homologous chromosome pairing, synapsis, and crossover. Polyploidy is a major driver of plant evolution, but additional chromosome copies disrupt key meiotic steps, leading to sterility or genomic instability. Core scientific ...

Academic Background Microbiomes are among the most diverse ecosystems on Earth, consisting of hundreds of functionally distinct microbial populations interacting through complex resource exchange networks. However, a long-standing unresolved question is: How is this extraordinary diversity maintained through metabolic interactions among populations...

Academic Background Touch is one of the earliest developed human senses and is crucial for physical and mental well-being. However, with the increasing prevalence of virtual communication, the lack of tactile interaction in remote exchanges may lead to psychological issues such as anxiety and loneliness. Previous studies have shown that touch can e...

Academic Background Chemotherapy resistance is one of the major challenges in cancer treatment. Traditional research has primarily focused on biochemical mechanisms (e.g., drug efflux pumps, DNA repair, etc.), but in recent years, the role of biomechanical factors in tumor progression and drug resistance has gained increasing attention. Studies hav...

1. Research Background The Parkinson’s disease-associated protein PARK7/DJ-1 (hereafter referred to as PARK7) is a multifunctional protein that plays critical roles in various pathological conditions including neurodegenerative diseases, cancer, and inflammation. Despite lacking a conventional N-terminal signal peptide sequence, PARK7 can be secret...

Academic Background Biomolecular condensates are membrane-less organelles formed through liquid-liquid phase separation (LLPS) within cells, playing critical roles in key biological processes such as gene expression and signal transduction. However, due to limitations in traditional imaging techniques, high-resolution structural information about t...

1. Research Background Atherosclerosis is the primary pathological basis of cardiovascular diseases, closely associated with endothelial cell (EC) dysfunction. Hemodynamic factors play a critical role in the regional selectivity of atherosclerosis: oscillatory shear stress (OS) (e.g., at vascular bifurcations) promotes plaque formation, while pulsa...

1. Academic Background and Research Motivation With the rapid development of life sciences and bioinformatics, research into RNA molecular structure and function has become a hot topic. RNA is not merely a carrier of genetic information, but also plays critical roles in regulation, catalysis, and various physiological processes. The three-dimension...