Chemical Space-Property Predictor Model of Perovskite Materials by High-Throughput Synthesis and Artificial Neural Networks

Chemical Space-Property Predictor Model of Perovskite Materials by High-Throughput Synthesis and Artificial Neural Networks

Academic Background Perovskite materials have attracted extensive attention due to their wide applications in solar cells and other electronic devices. Their optical properties (such as bandgap and lattice vibrations) can be flexibly modulated by tuning the chemical composition. Although the prediction of optical properties from perovskite structur...

Boosting Narrow-Band Near-Infrared-Emitting Efficiency of Thulium by Lattice Modulation for Reflective Absorption Bioimaging

Boosting Narrow-Band Near-Infrared-Emitting Efficiency of Thulium by Lattice Modulation for Reflective Absorption Bioimaging

Research Background Near-infrared (NIR) light holds significant application value in the biomedical field, particularly in non-invasive high-resolution imaging. NIR light can penetrate biological tissues and exhibits notable absorption differences for oxygenated and deoxygenated hemoglobin at specific wavelengths (e.g., 800 nm), making it an ideal ...

De Novo Luciferases Enable Multiplexed Bioluminescence Imaging

De Novo Luciferases Enable Multiplexed Bioluminescence Imaging

Academic Background Bioluminescence technology is a highly sensitive and non-invasive imaging technique, enabling real-time monitoring in living organisms without the need for external light sources. Luciferase is the key enzyme that catalyzes the light-emitting reaction, but natural luciferases face multiple limitations, such as poor protein foldi...

Hybrid Photoanodes Based on Surface-Bound Host-Guest Molecular Assemblies

Academic Background In the field of solar energy conversion, molecular catalysts have attracted significant attention due to their high activity and structural tunability. However, most molecular catalysts operate under homogeneous conditions, which are not favorable for large-scale and recyclable utilization. Therefore, immobilizing molecular cata...

Modulating Hetero-Multimetallic Atoms in Covalent Organic Frameworks for Efficient Oxidization of Olefin Compounds

In the field of synthetic chemistry, modulating the quantity and location of different metal centers to achieve synergistic, tandem, or cooperative effects has always been a technical challenge. Hetero-multinuclear catalysts have garnered significant attention due to their advantages such as high selectivity, cascading production, and specific chem...

Live Bacterial Chemistry in Biomedicine

Background Introduction The application of live bacteria in the biomedical field has garnered significant attention in recent years. Traditionally, bacteria were viewed as pathogens that needed to be eradicated. However, with the advancement of modern bacteriology, there has been a growing recognition of the complex symbiotic relationship between b...

Synthesis of Securingine B Enables Photoresponsive Materials Design

Research Background Natural products have long played a crucial role in drug discovery, providing many biologically active compounds and fundamental principles for drug development. However, the synthetic exploration of natural products is not limited to the pharmaceutical field; their applications in materials science are gradually gaining attenti...

The Interpeduncular Nucleus Blunts the Rewarding Effect of Nicotine

Nicotine is the primary addictive substance in tobacco, promoting smoking behavior by activating the brain’s dopamine reward system. Although the mechanisms of nicotine addiction have been extensively studied, the specific pathways through which it acts in the brain, particularly how it modulates reward and aversion through different neural circuit...

Alpha-Synuclein Mutations Mislocalize Cytoplasmic p300 Compromising Autophagy, Which Is Rescued by ACLY Inhibition

Academic Background Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, characterized by motor dysfunction, loss of dopaminergic neurons, and abnormal accumulation of alpha-synuclein (α-syn). Although the cause of most PD cases remains unclear, approximately 5%-10% of cases are due to monogenic mutations. The SNCA gene, w...

Anatomically Resolved Oscillatory Bursts Reveal Dynamic Motifs of Thalamocortical Activity During Naturalistic Stimulus Viewing

Research Background The visual system is one of the most complex sensory systems in the mammalian brain, relying on the coordinated activity of multiple brain regions, particularly the information transfer between the thalamus and the primary visual cortex (V1). The processing of visual information involves not only the extraction of basic features...