Academic Background Neurodegenerative diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), are often accompanied by abnormal aggregation and propagation of pathological proteins. The abnormal aggregation of α-synuclein is a central pathological feature of Parkinson’s disease and other synucleinopathies. Although extensive resear...

Academic Background Sleep plays a crucial role in memory formation, particularly non-rapid eye movement (NREM) sleep, which is considered a critical stage for memory consolidation. However, the specific mechanisms underlying memory consolidation, especially how intracellular signaling molecules coordinate with neural activity, remain a mystery. Cyc...

Academic Background Stroke is one of the leading causes of adult disability globally, with the core issue being neuronal damage and neurological dysfunction. Although neurogenesis and neurorepair after stroke are considered crucial for recovery, the specific mechanisms remain incompletely understood. Recent studies have shown that immune cells play...

Academic Background The somatosensory system plays a crucial role in processing diverse sensory signals such as mechanical, thermal, pain, and itch sensations. These signals are transmitted through various types of peripheral afferents to the spinal cord, where they are extensively processed and integrated before being relayed to the brain by spina...

Academic Background Cognitive control is the ability to flexibly adjust behavior according to goals and contexts, and the prefrontal cortex (PFC) plays a crucial role in this process. Previous research suggested that the PFC reads out rules from high-dimensional representations of task variables to guide behavior. However, increasing evidence indic...

Academic Background TDP-43 (TAR DNA-binding protein 43) is an RNA-binding protein primarily located in the nucleus, involved in multiple processes of RNA metabolism, including transcription, splicing, RNA transport, and translation. However, in various neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementi...

Alzheimer’s Disease (AD) is the most common form of dementia, characterized by the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain, leading to the progressive deterioration of brain function. Although Aβ plaques and NFTs have long been considered hallmarks of AD pathology, therapeutic strategies targeting t...

Neurons are the fundamental computational units of the brain, and their morphology and connectivity determine the brain’s computational capabilities. The diversity of neurons is driven by a series of waves of gene expression that guide cells through rapid developmental events, ultimately defining neuronal identity. Traditional experiments have show...

Chronic pain is a complex multidimensional experience involving sensory, emotional, and cognitive dimensions. Although traditional analgesic and antidepressant drugs are widely used, more than 50%-60% of chronic pain patients fail to benefit from them. Therefore, finding new treatment strategies has become an urgent need. In recent years, neuromodu...

Academic Background Mitochondria are the energy factories of cells, and the integrity of the mitochondrial inner membrane (MIM) is crucial for cellular function. Prohibitin (PHB) is a highly conserved protein family, consisting of two subtypes, PHB1 and PHB2, which play important roles in various cellular processes, including mitochondrial stress s...