Academic Background Ribophagy is a selective autophagy process responsible for regulating the degradation and turnover of ribosomes. Ribosomes are the core machinery for protein synthesis in cells, and their synthesis and degradation are crucial for cellular adaptation to environmental changes, such as nutrient deprivation. Under nutrient-rich cond...
Academic Background In eukaryotic cells, the transport from the endoplasmic reticulum (ER) to the Golgi apparatus is a central process of the secretory system, responsible for the spatiotemporal sorting of proteins and lipids. However, the nature of the ER-Golgi intermediate compartment (ERGIC) and the molecular mechanisms mediating the transition ...
Academic Background Alzheimer’s disease (AD) is the most common neurodegenerative disorder among the elderly, characterized by the pathological features of amyloid-beta (Aβ) deposits and hyperphosphorylated tau protein. Although aging is the most prominent risk factor for AD, the cellular mechanisms linking the decline in neuronal proteostasis to t...
Academic Background Extracellular vesicles (EVs) are crucial mediators of intercellular communication, carrying proteins, lipids, and genetic information to participate in various physiological and pathological processes. However, our understanding of EVs remains incomplete, particularly regarding the study of exceptionally large EVs. To address th...
In cell biology, the glycosylation modification of cell surface glycoproteins plays a crucial role in processes such as cell signaling, adhesion, and migration. How dynamic changes in glycosylation regulate intracellular transport and function, particularly the internalization of cell surface receptors through endocytosis, remains an incompletely u...
Background Introduction In cell biology, understanding how cells respond differently to perturbations is crucial. Perturbation refers to altering cell states through gene editing, chemical substances, environmental changes, or mechanical forces to study their functions. However, existing methods have limitations in quantifying heterogeneous respons...
Academic Background and Problem Introduction Chronic Myeloid Leukemia (CML) is a hematologic malignancy driven by the BCR-ABL1 fusion gene. Although Tyrosine Kinase Inhibitors (TKIs) have significantly improved the survival rate of CML patients, TKI resistance and disease progression to the blast crisis (BC) phase remain major challenges in clinica...
Tumor heterogeneity is a critical issue in cancer research, encompassing genetic, phenotypic, and microenvironmental heterogeneity. Although single-cell sequencing has shed light on genetic and phenotypic heterogeneity, the study of non-genetic factors, such as microenvironmental heterogeneity, remains insufficient. Oxidative stress is a hallmark o...
In the field of functional genomics, researchers have long been dedicated to predicting causal regulatory relationships from observational data. However, despite modern technologies enabling the measurement of diverse molecular modalities, inferring causal regulatory relationships from observational data remains challenging. In particular, the iden...
The occurrence and progression of cancer are closely related to the expression of oncogenes, and the regulation of oncogene expression is a complex process. Among these mechanisms, the role of translation control in oncogene expression has gradually gained attention. MYC is a key oncogene that is overexpressed in various cancers, particularly in pa...