Soft X-ray Prompt Emission from the High-Redshift Gamma-Ray Burst EP240315A

Study on Soft X-ray Prompt Emission from the High-Redshift Gamma-Ray Burst EP240315A Background Gamma-Ray Bursts (GRBs) are among the most violent explosive events in the universe, typically lasting from milliseconds to hundreds of seconds. Long Gamma-Ray Bursts (Long GRBs) are believed to originate from the core collapse of massive stars, making t...

Propagation of Pathologic α-Synuclein from Kidney to Brain May Contribute to Parkinson’s Disease

Pathological Link Between Kidney Disease and Parkinson’s Disease Academic Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the abnormal aggregation of α-synuclein (α-syn) in the brain, forming Lewy bodies (LBs) and Lewy neurites (LNs). In recent years, increasing evidence suggests that the pathological agg...

Neural Mechanisms of Relational Learning and Fast Knowledge Reassembly in Plastic Neural Networks

Neural Mechanisms and Relational Learning: Rapid Knowledge Reassembly in Neural Networks Background Humans and animals possess a remarkable ability to learn relationships between items in experience (such as stimuli, objects, and events), enabling structured generalization and rapid information assimilation. A fundamental type of such relational le...

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification Academic Background Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. The disease is caused by a CAG repeat expansion in the HTT gene, leading to ab...

Partial Differentiation of Europa and Implications for the Origin of Materials in the Jupiter System

Partial Differentiation of Europa and Implications for the Origin of Materials in the Jupiter System Academic Background Europa, one of Jupiter’s icy moons, has long been considered one of the most promising candidates for extraterrestrial life in the solar system. Its surface is covered by a thick ice layer, beneath which a liquid water ocean may ...

A Distinct Hypothalamus–Habenula Circuit Governs Risk Preference

Study on the Hypothalamus-Habenula Circuit Regulating Risk Preference Academic Background In complex and uncertain environments, animals need to assess risks to make survival-favorable decisions. When faced with safe and risky options, animals usually exhibit a strong preference for one option, which remains consistent over time. However, how this ...

Interdisciplinary Advances in Microcombs: Bridging Physics and Information Technology

Interdisciplinary Advances in Microcomb Technology: Bridging Physics and Information Technology Academic Background The optical frequency comb (OFC) is a technology that divides the optical frequency domain into a series of discrete, equally spaced frequency lines. It has been widely used in precision measurements, optical communications, atomic cl...

A Large Field-of-View, Single-Cell-Resolution Two- and Three-Photon Microscope for Deep and Wide Imaging

A Large Field-of-View, Single-Cell-Resolution Two- and Three-Photon Microscope for Deep and Wide Imaging

Large field-of-view, single-cell-resolution two- and three-photon microscope for deep and wide imaging Research Background and Problem Statement Multiphoton microscopy (MPM) is a powerful tool for deep tissue imaging, especially in the study of brain function in vivo. However, while traditional two-photon microscopy (2PM) can achieve a larger imagi...

A Spatial-Frequency Patching Metasurface Enabling Super-Capacity Perfect Vector Vortex Beams

The Realization of Super-Capacity Perfect Vector Vortex Beams Research Background and Problem Statement Optical vortices, with their unique orbital angular momentum (OAM) characteristics, have demonstrated great potential in applications such as optical multiplexing, particle manipulation, imaging, holographic display, optical communication, and op...

Review of Ultrafast Nano-Spectroscopy and Nano-Imaging Applications with Tip-Based Microscopy

Latest Advances in Ultrafast Nano-Spectroscopy and Imaging Technologies: Applications of Tip-Based Microscopy Research Background In recent years, with the rapid development of optical microscopy technology, scientists have made significant progress in understanding nanoscale physical phenomena. However, traditional far-field optical microscopy is ...