Isolation and Identification of Three New Isomer Impurities in Milbemycin Oxime Drug Substance

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Pharmacy,
Milbemycin Oxime   Isomer Impurities   Isolation   Identification   Drug Analysis   HPLC   NMR  

Isolation and Identification of Three New Isomer Impurities in Milbemycin Oxime Drug Substance Academic Background Milbemycins are a class of 16-membered macrolides produced by Streptomyces, exhibiting potent anthelmintic and insecticidal activities with low mammalian toxicity. Milbemycins and their derivatives are widely used in agriculture and ve...

Antimicrobial Activity of α/β Hybrid Peptides Incorporating tbu-β3,3ac6c Against Methicillin-Resistant Staphylococcus aureus

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Life Sciences, Microbiology,
antimicrobial peptides   methicillin-resistant Staphylococcus aureus   β-amino acids   multi-drug resistance   antimicrobial activity   peptide synthesis   biofilm inhibition  

Antimicrobial Activity of Novel α/β Hybrid Peptides Against Methicillin-Resistant Staphylococcus aureus (MRSA) Research Background With the widespread use and misuse of antibiotics, multi-drug resistance (MDR) has become a major global public health threat. Particularly, ESKAPE pathogens (including Enterococcus faecium, Staphylococcus aureus, Klebs...

Structure-Activity Relationship Studies of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Pharmacy,
onychomycosis   antifungal agent   structure-activity relationship   topical treatment   ME1111   nail permeability   keratin binding  

Structure-Activity Relationship Studies of ME1111—A Novel Antifungal Agent for Topical Treatment of Onychomycosis Background Onychomycosis is a globally prevalent disease affecting approximately 5.5% of the world’s population. Among its subtypes, distal-lateral subungual onychomycosis (DLSO) is the most common. The treatment of onychomycosis typica...

Circulating Tumor DNA Trajectories Predict Survival in Trifluridine/Tipiracil-Treated Metastatic Colorectal Cancer Patients

Medicine, Oncology,
Circulating Tumor DNA   Metastatic Colorectal Cancer   Trifluridine/Tipiracil   Survival Rate   Molecular Biomarkers   Treatment Response   Prognosis  

ctDNA Trajectories Predict Survival in Trifluridine/Tipiracil-Treated Metastatic Colorectal Cancer Patients Academic Background Metastatic colorectal cancer (mCRC) is one of the leading causes of cancer-related deaths worldwide. Despite recent advancements in diagnosis and treatment, the prognosis for advanced-stage patients remains poor. Triflurid...

Combination of Biological Aging and Genetic Susceptibility Helps Identifying At-Risk Population of Venous Thromboembolism: A Prospective Cohort Study of 394,041 Participants

Medicine, Geriatrics, Hematology, Cardiovascular System, Life Sciences, Genetics,
biological aging   phenotypic age   polygenic risk score   risk stratification   venous thromboembolism  

Combining Biological Aging and Genetic Susceptibility to Identify High-Risk Populations for Venous Thromboembolism Academic Background Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most fatal cardiovascular disease globally. The incidence of VTE is closely related to age, particularly i...

CM313 Monotherapy in Patients with Relapsed/Refractory Multiple Myeloma or Marginal Zone Lymphoma: A Multicenter, Phase 1 Dose-Escalation and Dose-Expansion Trial

Medicine, Hematology, Oncology,
Multiple Myeloma   Marginal Zone Lymphoma   CM313   Dose-Escalation   Safety   Efficacy   Clinical Trial  

CM313 Monotherapy in Patients with Relapsed/Refractory Multiple Myeloma or Marginal Zone Lymphoma: A Multicenter Phase 1 Dose-Escalation and Expansion Trial Academic Background Multiple Myeloma (MM) is a common hematologic malignancy, accounting for approximately one-tenth of all hematologic malignancies. Although the use of immunomodulatory drugs ...