Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERP57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
ALS   protein disulfide isomerase   ERP57   TDP-43 pathology   ER stress  

Study on the Protective Effect of ERP57 on ALS-related Mutant TDP-43 in Neuronal Cells Introduction Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease affecting motor neurons. Almost all ALS cases (97%) and about 50% of frontotemporal dementia (FTD) cases show a pathological form of Tar-DNA binding protein-43 (TDP-43), indica...

Association of NID2 SNPs with Glioma Risk and Prognosis in the Chinese Population

Association of NID2 SNPs with Glioma Risk and Prognosis in the Chinese Population

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Genetics,
NID2   single-nucleotide polymorphisms   glioma   risk   prognosis  

Association of NID2 gene single nucleotide polymorphisms with glioma risk and prognosis in Chinese Han population Academic Background Glioma is the most common primary intracranial tumor, characterized by high mortality and poor prognosis. Despite some progress in diagnostic and treatment strategies, conventional therapies have limited improvement ...

FMOD Alleviates Depression-like Behaviors by Targeting the PI3K/AKT/mTOR Signaling Pathway after Traumatic Brain Injury

Medicine, Psychiatry, Neurology, Clinical Psychology,
TBI   depression   FMOD   synaptic plasticity   PI3K/AKT/mTOR  

Research Report on FMOD Alleviating Depressive Behavior After Traumatic Brain Injury Traumatic Brain Injury (TBI) is a global health issue with far-reaching impacts, causing not only brain dysfunction but also often leading to mental disorders. One of the most common mental illnesses following TBI is depression, affecting approximately 25-50% of TB...

Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

Medicine, Pediatrics, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry,
rosmarinic acid   epidermal growth factor receptor   histone deacetylase inhibitor   stem cell-like phenotype   medulloblastoma   brain tumor  

Pediatric medulloblastoma (MB) is the most common malignant pediatric brain tumor. Due to its unique molecular and clinical characteristics, the treatment of this type of tumor has been a focus of clinical research. Existing treatments mainly include maximal surgical resection, radiotherapy, and chemotherapy, but these treatments often lead to long...

Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-Ion Rat

Medicine, Basic Medical Sciences, Anesthesiology, Neurology, Neurosurgery,
optogenetics   neuron inhibition   posterior insular cortex   trigeminal neuropathic pain   CCI-Ion  

Optogenetic Inhibition of Insular Cortex Glutamatergic Neurons Regulates Trigeminal Neuropathic Pain Introduction and Background Trigeminal neuropathic pain (TNP) is a severe facial disorder characterized by rapid and intense stabbing pain attacks that spread along the cutaneous segments of the trigeminal nerve. TNP occurs almost twice as frequentl...

Neuroprotective Effects of Sinomenine on Experimental Autoimmune Encephalomyelitis via Anti-inflammatory and Nrf2-dependent Anti-oxidative Stress Activity

Medicine, Neurology,
Sinomenine   Experimental Autoimmune Encephalomyelitis   Multiple Sclerosis   Neuroinflammation   Oxidative Stress   Nrf2  

Research Background on Multiple Sclerosis and Central Nervous System Inflammation Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS), often accompanied by chronic inflammation, leading to oligodendrocyte loss, activation of brain-resident immune cells, blood-brain barrier disruption, extensive demyelin...