Perinatal Dysfunction of Innate Immunity in Cystic Fibrosis

Medicine, Infectious Diseases, Pediatrics, Rheumatology and Immunology, Respiratory System, Life Sciences, Immunology,
Cystic Fibrosis   Innate Immunity   Perinatal   Lung Damage   Inflammation   Monocytes   Transcriptomic Profiling  

Study on Congenital Immune Dysfunction in Cystic Fibrosis Research Background Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, primarily affecting the lungs and digestive system. One of the major problems faced by CF patients is recurrent infections and inflammatio...

Development and Validation of a Time-Varying Correction Factor for QT Interval Assessment in Drug-Resistant Tuberculosis Patients

Medicine, Infectious Diseases, Pharmacy, Cardiovascular System, Life Sciences, Biochemistry,
drug-resistant tuberculosis   tachycardia   heart rate   QT interval   QT prolongation   correction factors  

Development and Validation of a Time-Varying Correction Factor for QT Interval Assessment in Drug-Resistant Tuberculosis Patients Academic Background and Research Motivation During the treatment of active tuberculosis (Tuberculosis, TB), patients often experience tachycardia (Tachycardia), which typically diminishes as they recover. Elevated heart ...

Serum NfL and Neuropsychological Performance over ∼8 Years in Women with and without HIV: A Longitudinal Repeated Measures Study

Medicine, Infectious Diseases, Neurology,
cognition   HIV   neurofilament light chain   women   longitudinal study  

Serum Neurofilament Light Chain and Cognitive Performance in Women with and without HIV: A Longitudinal Study Over Approximately 8 Years Research Background With the widespread use of highly active antiretroviral therapy (ART), the life expectancy of individuals infected with human immunodeficiency virus (HIV) has significantly increased. However, ...

5-HT7R Enhances Neuroimmune Resilience and Alleviates Meningitis by Promoting CCR5 Ubiquitination

Medicine, Infectious Diseases, Rheumatology and Immunology, Basic Medical Sciences, Neurology, Life Sciences, Immunology,
5-HT7R   meningitis   neuroimmune   ubiquitination   CCR5   STUB1  

5-HT7R Enhances Neuroimmune Resilience and Alleviates Meningitis by Promoting CCR5 Ubiquitination Academic Background Bacterial meningitis is a rapidly onset, highly fatal disease with epidemic potential, especially when caused by Streptococcus pneumoniae (S.p.) infection. The destruction of the blood-brain barrier (BBB) leads to the release of inf...

Prevalence and Incidence of Comorbidities in Patients with Atopic Dermatitis, Psoriasis, Alopecia Areata, and Vitiligo Using a Japanese Claims Database

Medicine, Infectious Diseases, Rheumatology and Immunology, Oncology, Cardiovascular System, Life Sciences, Immunology,
comorbidities   atopic dermatitis   psoriasis   alopecia areata   vitiligo   Japan   health claims database  

Prevalence and Incidence of Comorbidities in Japanese Patients with Dermatologic Diseases Academic Background Dermatologic diseases such as atopic dermatitis (AD), psoriasis, alopecia areata (AA), and vitiligo are common chronic inflammatory or autoimmune skin disorders. These conditions not only significantly impact patients’ quality of life but a...

Validation of Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score and Establishment of Novel Score in Japanese Patients with Necrotizing Fasciitis (J-LRINEC Score)

Medicine, Infectious Diseases,
necrotizing fasciitis   LRINEC score   Japanese patients   sensitivity   specificity   skin infection   J-LRINEC  

A Report on the Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score and the Establishment of a Novel Score (J-LRINEC) in Japanese Patients Academic Background Necrotizing fasciitis (NF) and cellulitis are two common skin infectious diseases. Although they share some similarities in clinical manifestations, their sev...