Epstein–Barr Virus Infection Exacerbates Ulcerative Colitis by Driving Macrophage Pyroptosis via the Upregulation of Glycolysis

Medicine, Infectious Diseases, Gastroenterology, Life Sciences, Immunology,
Epstein-Barr virus   ulcerative colitis   macrophages   pyroptosis   glycolysis  

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent inflammation and ulceration of the colonic mucosa. Current treatments for UC primarily rely on immunosuppressive drugs, such as corticosteroids, immunomodulators, and biologics. However, the immunosuppressive properties of these drugs incr...

Targeted Nuclear Degranulation of Neutrophils Promotes the Progression of Pneumonia in Ulcerative Colitis

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophils   targeted nuclear degranulation   ulcerative colitis   pneumonia   immune cell migration  

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease often accompanied by various extraintestinal complications, among which pulmonary infections are particularly severe. Although previous studies have indicated interactions between the intestinal and pulmonary immune systems, the specific mechanisms involving neutrop...

APNet: An Explainable Sparse Deep Learning Model to Discover Differentially Active Drivers of Severe COVID-19

Information Science, Artificial Intelligence, Medicine, Infectious Diseases, Life Sciences, Immunology,
COVID-19   deep learning   bioinformatics   proteomics   network biology  

Academic Background The COVID-19 pandemic has had a significant impact on global public health systems. Although the pandemic has somewhat subsided, its complex immunopathological mechanisms, long-term sequelae (such as “long COVID”), and the potential for similar threats in the future continue to drive in-depth research. Severe COVID-19 cases are ...

A Portable, Sprayable, Highly Malleable, Elastic, and Hydrophobic Antibacterial Fibrous Wound Dressing for Infected Wound Healing

Chemistry, Nanoscience, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Medicine, Infectious Diseases, Life Sciences, Bioengineering,
wound dressing   antibacterial   hydrophobic   malleability   solution blow spinning   infected wound   wound healing  

Academic Background Wound infection is a significant concern for patients and healthcare professionals worldwide, particularly in the management of severe wounds. Inappropriate dressings can increase the risk of infection, prolong healing time, and even lead to higher mortality rates and economic burdens. Traditional wound dressings, such as gauze ...

Are Contemporary Antifungal Doses Sufficient for Critically Ill Patients? Outcomes from an International, Multicenter Pharmacokinetics Study for Screening Antifungal Exposure in Intensive Care Units—The SAFE-ICU Study

Medicine, Infectious Diseases, Pharmacy,
antifungals   pharmacokinetics   intensive care unit   invasive fungal disease   dose optimization  

International Multicenter Study Reveals Insufficient Antifungal Dosing in Critically Ill Patients Academic Background Invasive fungal infections are common and serious nosocomial infections, particularly among patients in the intensive care unit (ICU), where they are associated with high morbidity and mortality rates. Timely and appropriate antifun...

Impact of Rapid ICU-Based Syndromic PCR on Antibiotic Stewardship and Clinical Outcomes in Hospital-Acquired and Ventilator-Associated Pneumonia

Medicine, Infectious Diseases, Medical Laboratory Science,
Hospital-acquired pneumonia   Ventilator-associated pneumonia   Multiplex PCR   Antibiotic stewardship   Clinical outcomes  

INHALE WP3 Study - The Impact of Rapid PCR on ICU Antibiotic Stewardship and Clinical Outcomes Background Introduction Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are common infections in intensive care unit (ICU) patients, with an incidence rate between 5% to 40%, and are associated with high morbidity and increased...