Impact of Rapid ICU-Based Syndromic PCR on Antibiotic Stewardship and Clinical Outcomes in Hospital-Acquired and Ventilator-Associated Pneumonia

Medicine, Infectious Diseases, Medical Laboratory Science,
Hospital-acquired pneumonia   Ventilator-associated pneumonia   Multiplex PCR   Antibiotic stewardship   Clinical outcomes  

INHALE WP3 Study - The Impact of Rapid PCR on ICU Antibiotic Stewardship and Clinical Outcomes Background Introduction Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are common infections in intensive care unit (ICU) patients, with an incidence rate between 5% to 40%, and are associated with high morbidity and increased...

A Multivariable Prediction Model for Invasive Pulmonary Aspergillosis in Immunocompromised Patients with Acute Respiratory Failure (IPA-GRRR-OH Score)

Medicine, Infectious Diseases, Oncology, Life Sciences, Immunology,
Invasive Pulmonary Aspergillosis   Immunocompromised   Acute Respiratory Failure   Prediction Model   Intensive Care  

A Prediction Model for Invasive Pulmonary Aspergillosis in Immunocompromised Patients with Acute Respiratory Failure Background Introduction Invasive Pulmonary Aspergillosis (IPA) is a severe opportunistic infection commonly seen in immunocompromised patients, particularly those with immune dysfunction caused by hematological malignancies, stem cel...

Novel Endocytosis Inhibitors Block Entry of HIV-1 Tat into Neural Cells

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Neurology, Life Sciences, Biochemistry, Immunology,
HIV-1 Tat   endocytosis inhibitors   oxidative stress   DNA damage   neural cells  

Novel Endocytosis Inhibitors Block HIV-1 Tat Protein Entry into Neural Cells Academic Background HIV-1 (human immunodeficiency virus type 1) infection not only leads to immune system exhaustion but is also closely associated with HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) has significantly improv...

Prior Vaccination Prevents Overactivation of Innate Immune Responses During COVID-19 Breakthrough Infection

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Biochemistry, Immunology,
COVID-19   breakthrough infection   innate immune response   vaccination   sex-specific patterns  

How COVID-19 Vaccines Affect Immune Responses During Breakthrough Infections Background Introduction As the COVID-19 pandemic continues, an increasing number of infections are “breakthrough infections,” occurring in individuals who have been vaccinated or previously infected with SARS-CoV-2. Although vaccination has significantly reduced the risk o...

Pseudomonas aeruginosa Infection Induces Lung Transplant Antibody-Mediated Rejection

Medicine, Infectious Diseases, Life Sciences, Immunology,
Pseudomonas aeruginosa   lung transplantation   antibody-mediated rejection   lymphocytotoxicity   bacterial infection  

Pseudomonas aeruginosa Infection Induces Antibody-Mediated Rejection in Lung Transplantation Academic Background Introduction Lung transplantation is a critical treatment for end-stage lung diseases, but post-transplant rejection remains a major challenge affecting long-term patient survival. Antibody-mediated rejection (AMR) is an increasingly rec...

Perinatal Dysfunction of Innate Immunity in Cystic Fibrosis

Medicine, Infectious Diseases, Pediatrics, Rheumatology and Immunology, Respiratory System, Life Sciences, Immunology,
Cystic Fibrosis   Innate Immunity   Perinatal   Lung Damage   Inflammation   Monocytes   Transcriptomic Profiling  

Study on Congenital Immune Dysfunction in Cystic Fibrosis Research Background Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, primarily affecting the lungs and digestive system. One of the major problems faced by CF patients is recurrent infections and inflammatio...