Validation of Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score and Establishment of Novel Score in Japanese Patients with Necrotizing Fasciitis (J-LRINEC Score)

Medicine, Infectious Diseases,
necrotizing fasciitis   LRINEC score   Japanese patients   sensitivity   specificity   skin infection   J-LRINEC  

A Report on the Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score and the Establishment of a Novel Score (J-LRINEC) in Japanese Patients Academic Background Necrotizing fasciitis (NF) and cellulitis are two common skin infectious diseases. Although they share some similarities in clinical manifestations, their sev...

The Impact of Antibiotic Therapy in Psoriasis Patients with Active Streptococcal Infection: A Prospective Study

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Immunology,
psoriasis   streptococcal infection   antibiotic therapy   psoriasis area and severity index   pharyngeal infection  

The Impact of Antibiotic Therapy on Psoriasis Patients with Streptococcal Infection Academic Background Psoriasis is a chronic, relapsing inflammatory systemic skin disease with a global prevalence of around 2%-3%. Although its pathogenesis is not fully understood, studies suggest that bacterial, viral, and fungal infections may induce or exacerbat...

Repurposing Diacerein for the Treatment of Chronic Wounds in Recessive-Dystrophic Epidermolysis Bullosa Patients by Modulating Matrix Metalloproteinase-9 Expression

Medicine, Infectious Diseases, Life Sciences, Immunology,
diacerein   matrix metalloproteinase-9   recessive-dystrophic epidermolysis bullosa   chronic wounds   skin inflammation  

Research Background Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic skin disorder caused by mutations in the COL7A1 gene, leading to the absence or dysfunction of type VII collagen (C7). Type VII collagen is a crucial protein for maintaining skin structural stability, and its deficiency makes patients’ skin extremely fragile, pr...

Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing

Chemistry, Nanoscience, Inorganic Chemistry, Polymer Chemistry, Medicine, Infectious Diseases, Rheumatology and Immunology, Pharmacy, Life Sciences, Biochemistry, Bioengineering, Immunology,
Infected wounds   Hydrogels   Polyphenols   Gallium ions   Antibacterial activity   Antibiotic-resistant pathogens   Wound healing  

A Novel Study on Multifunctional Hydrogels for Promoting Infected Wound Healing In the current clinical setting, infected wounds, especially those caused by antibiotic-resistant pathogens, have become a major challenge. These chronic or hard-to-heal wounds often suffer from delayed healing processes due to excessive inflammation, bacterial biofilm ...

A Potential 3-in-1 Combined Anti-SARS-CoV-2 Therapy Using Pulmonary MIL-100(Fe) Formulation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Infectious Diseases, Respiratory System, Pharmacy, Life Sciences, Biochemistry, Immunology,
COVID-19   metal-organic frameworks   antiviral therapy   pulmonary treatment   Favipiravir   heparin   drug delivery  

Exploration of a Novel Pulmonary Anti-SARS-CoV-2 Therapy Based on MIL-100(Fe) In recent years, global public health has faced numerous severe challenges, particularly since 2019 with the outbreak of the SARS-CoV-2 coronavirus pandemic. The high transmission rate and persistence of the virus have exposed bottlenecks in current prevention and treatme...

A Dual-Pipeline Lactate Removal Strategy to Reverse Vascular Hyperpermeability for the Management of Lipopolysaccharide-Induced Sepsis

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Infectious Diseases, Basic Medical Sciences, Life Sciences, Biochemistry, Bioengineering, Immunology,
lactate removal   vascular hyperpermeability   sepsis   lipopolysaccharides   nanohybrids   inflammatory response   endothelial barrier function  

A Novel Dual-Pipeline Lactate Removal Strategy for Sepsis Treatment Background Sepsis, defined as multi-organ dysfunction caused by a dysregulated host immune response to bloodborne infection, remains a severe global public health issue. Despite advances in modern medicine, the diagnosis and treatment of sepsis pose significant challenges. Statisti...