Differential Gene Expression Analysis Shows That Cephalosporin Resistance is Intrinsic to Clostridioides difficile Strain 630

Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
Clostridioides difficile   cephalosporin resistance   gene expression   β-lactamase   ABC transporter   antibiotics   transcriptomic analysis  

Research on Cephalosporin Resistance in C. difficile Background Clostridioides difficile infection (CDI) is one of the most common hospital-acquired infections in the United States, leading to a significant number of hospitalizations and even deaths annually. CDI not only poses a threat to patient health but also imposes a substantial economic burd...

Identification of Nanaomycin A and Its Analogs by a Newly Established Screening Method for Functional Inhibitors of the Type IX Secretion System in Porphyromonas gingivalis

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Oral Sciences, Life Sciences, Biochemistry, Microbiology,
Nanaomycin A   Porphyromonas gingivalis   Type IX Secretion System   Functional Inhibitors   Periodontal Disease   Screening Method   Proteolytic Enzymes  

Identification of Nanaomycin A and Its Analogs as Functional Inhibitors of the Type IX Secretion System in Porphyromonas gingivalis Using a Novel Screening Method Academic Background Porphyromonas gingivalis is a Gram-negative anaerobic bacterium recognized as one of the primary pathogens in chronic periodontitis. Beyond periodontal diseases, P. gi...

Thiazoplanomicin, a New Thiazolyl Peptide Antibiotic from the Leaf-Litter Actinomycete Actinoplanes sp. MM794L-181F6

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Life Sciences, Microbiology,
thiazolyl peptide antibiotic   antibacterial activity   drug resistance   actinomycetes   new antibiotic  

Discovery and Research of the New Antibiotic Thiazoplanomicin Academic Background In recent years, the issue of antibiotic resistance has become increasingly severe, particularly with Neisseria gonorrhoeae (gonococcus), a common sexually transmitted pathogen. Gonococcus can rapidly develop drug resistance, rendering traditional antibiotics such as ...

Antimicrobial Activity of α/β Hybrid Peptides Incorporating tbu-β3,3ac6c Against Methicillin-Resistant Staphylococcus aureus

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Life Sciences, Microbiology,
antimicrobial peptides   methicillin-resistant Staphylococcus aureus   β-amino acids   multi-drug resistance   antimicrobial activity   peptide synthesis   biofilm inhibition  

Antimicrobial Activity of Novel α/β Hybrid Peptides Against Methicillin-Resistant Staphylococcus aureus (MRSA) Research Background With the widespread use and misuse of antibiotics, multi-drug resistance (MDR) has become a major global public health threat. Particularly, ESKAPE pathogens (including Enterococcus faecium, Staphylococcus aureus, Klebs...

Structure-Activity Relationship Studies of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Pharmacy,
onychomycosis   antifungal agent   structure-activity relationship   topical treatment   ME1111   nail permeability   keratin binding  

Structure-Activity Relationship Studies of ME1111—A Novel Antifungal Agent for Topical Treatment of Onychomycosis Background Onychomycosis is a globally prevalent disease affecting approximately 5.5% of the world’s population. Among its subtypes, distal-lateral subungual onychomycosis (DLSO) is the most common. The treatment of onychomycosis typica...

Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1

Medicine, Infectious Diseases, Cardiovascular System, Life Sciences, Microbiology,
Klebsiella pneumoniae   extracellular vesicles   endothelial dysfunction   endothelial senescence   SIRT1   hypertension   inflammatory response  

Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...