Academic Background During tissue repair, chronic hypoxia negatively impacts the functionality of stem cells. Periosteal Stem Cells (PSCs), as the primary contributors to bone repair, exhibit unclear behavior under hypoxic conditions. While hypoxia may be beneficial for certain stem cells in the early stages of tissue repair, prolonged hypoxia can ...

Study on the Role of KV7 Channels in Regulating Smooth Muscle Contraction in Mouse Corpus Cavernosum Academic Background Erectile dysfunction (ED) is a significant health issue that impacts the quality of life for men. Since the introduction of phosphodiesterase 5 (PDE5) inhibitors like Sildenafil in the 1990s, there has been notable progress in th...

Academic Report on the Role of Intestinal Epithelium-Derived IL-34 in Alleviating Graft-versus-Host Disease 1. Academic Background Graft-versus-Host Disease (GVHD) is a severe complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), and gastrointestinal (GI) GVHD is the primary determinant of morbidity and mortality du...

Mechanism Study on 5-Hydroxytryptamine Regulating Histone Modifications to Drive Liver Metastasis Academic Background Cancer metastasis is one of the leading causes of cancer patient mortality, especially visceral organ metastases such as liver metastasis (liver metastasis). Neuroendocrine tumors (NETs) are a class of highly metastatic tumors, amon...

5-HT7R Enhances Neuroimmune Resilience and Alleviates Meningitis by Promoting CCR5 Ubiquitination Academic Background Bacterial meningitis is a rapidly onset, highly fatal disease with epidemic potential, especially when caused by Streptococcus pneumoniae (S.p.) infection. The destruction of the blood-brain barrier (BBB) leads to the release of inf...