Study on GABRA4 Gene Mutations and Neurological Phenotypes

New Scientific Research Reveals Association Between GABRA4 Gene and Neurological Phenotypes Research Background In recent years, significant progress has been made in the study of epilepsy and developmental disorder syndromes associated with single gene mutations. GABAA receptors (gamma-aminobutyric acid sub-type A receptors, GABAARs) are heterogen...

Genetic Heterogeneity in Hereditary Hearing Loss: Potential Role of Kinociliary Protein TOGARAM2

Genetic Diversity in Hereditary Hearing Loss: The Potential Role of KINOCILIARY Protein TOGARAM2 Background Hearing Loss (HL) is a feature with multiple causes, and currently, research has identified pathogenic variants in over 200 genes associated with HL. Despite extensive research, the causative factor remains unidentified in more than one-third...

The Neurocomputational Mechanism Underlying Decision-Making on Unfairness to Self and Others

Neural computational mechanisms underlying fairness-based decisions: Self-Unfairness and Other-Unfairness Abstract: Fairness is a fundamental value in human society, and individuals show concern for both self-unfairness and other-unfairness. However, there has been a long-standing debate on whether self-unfairness and other-unfairness evoke shared ...

Cortical Morphological Networks Differ Between Gyri and Sulci

Differences in Brain Cortical Morphological Networks Between Gyri and Sulci Introduction The human brain, as an interconnected complex network, can be mapped through virtual imaging using multimodal magnetic resonance imaging (MRI) technology. By analyzing this network using graph theory methods, many studies have discovered some non-trivial topolo...

Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model

Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model Background Post-traumatic stress disorder (PTSD) is a complex mental disorder characterized by spontaneous intrusions of traumatic memories, avoidance of trauma-related stimuli, negative emotions and cognitions, and hyperarousal. Although existing first...