Epigallocatechin-3-Gallate Inhibits LPS/AβO-Induced Neuroinflammation in BV2 Cells Through Regulating the ROS/Txnip/NLRP3 Pathway

Medicine, Basic Medical Sciences, Neurology, Pharmacy, Life Sciences, Cell Biology, Biochemistry,
Alzheimer's Disease   Amyloid β   Epigallocatechin-3-Gallate   NLRP3 Inflammasome   Txnip  

Epigallocatechin-3-Gallate (EGCG) Inhibits Neuroinflammation in BV2 Cells by Regulating the ROS/TXNIP/NLRP3 Pathway Research Background Alzheimer’s Disease (AD) is a degenerative brain disorder primarily affecting the elderly, characterized by persistent cognitive dysfunction and behavioral impairment. The neuropathological changes in AD include β-...

Glycyrrhizic Acid Alleviates Semen Strychni-Induced Neurotoxicity Through the Inhibition of HMGB1 Phosphorylation and Inflammatory Responses

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry, Bioengineering,
Semen Strychni   Neurotoxicity   Glycyrrhizic Acid   HMGB1   Phosphorylation  

Research Report on the Mechanism of Glycyrrhizic Acid in Alleviating Neurotoxicity Induced by Semen Strychni Background Introduction Semen Strychni, derived from the dried mature seeds of Strychnos Nux-vomica, has been found to possess various pharmacological activities, including anti-tumor, anti-inflammatory, immunosuppressive, and neuroexcitator...

Endothelin-1-Mediated Brainstem Glial Activation Produces Asthmatic Airway Vagal Hypertonia via Enhanced ATP-P2X4 Receptor Signaling

Medicine, Respiratory System, Basic Medical Sciences, Neurology, Life Sciences, Immunology,
Endothelin-1   Brainstem glial activation   Airway vagal hypertonia   ATP-P2X4 receptor   Asthma   Sprague–Dawley rats  

Endothelin-1 Mediated Brainstem Glial Activation Produces Asthmatic Airway Vagal Hypertonia via Enhanced ATP-P2X4 Receptor Signaling Academic Background Asthma is one of the major non-communicable diseases globally, causing a heavy social and economic burden. Its main clinical symptoms include airflow obstruction, chronic airway inflammation, incre...

Potential Role of BMAL1 in Lipopolysaccharide-Induced Depression-Like Behavior and Its Associated "Inflammatory Storm"

Medicine, Infectious Diseases, Basic Medical Sciences, Psychiatry, Neurology, Life Sciences, Immunology,
depression   circadian rhythms   neuroinflammation   synaptic plasticity  

The Role of BMAL1 in LPS-Induced Depressive Behavior and Related “Inflammatory Storm” Introduction According to the 2019 Global Burden of Disease Study, mental disorders are listed as one of the top 10 causes of global burden, with depression being a major contributor. Over 350 million people worldwide suffer from depression, making it the most com...

Perioperative levels of IL8 and IL18, but not IL6, are associated with nucleus basalis magnocellularis atrophy three months after surgery

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Medical Laboratory Science, Geriatrics, Neurology, Medical Imaging,
nucleus basalis magnocellularis   acetylcholine   interleukins   surgery   atrophy   neurodegeneration  

Association Study of Perioperative IL8 and IL18 Levels with Brain Basal Ganglia Atrophy Three Months After Surgery Background In recent years, an increasing number of studies have shown that surgical procedures may accelerate brain atrophy. Meanwhile, the relationship between systemic inflammation and neurodegenerative diseases has also received co...