Integrated Analysis of Blood DNA Methylation, Genetic Variation, Circulating Proteins, microRNAs, and Kidney Failure in Type 1 Diabetes Research Background Diabetic Kidney Disease (DKD) is one of the major complications of Type 1 Diabetes (T1D). Approximately 40% of T1D patients develop DKD, and 10% to 15% eventually progress to Kidney Failure (KF)...

Scientists Reveal the Anti-Tumor Mechanism of Src Inhibitors in IDH Mutant Cholangiocarcinoma Background Introduction In recent years, the incidence of intrahepatic cholangiocarcinoma (ICC) has been rising worldwide. ICC is a highly invasive tumor usually lacking noticeable symptoms in the early stages, with cases often being inoperable by the time...

High-Fidelity Fatigue-Resistant Muscle Control Through Closed-Loop Optogenetic Neural Modulation Background Introduction Skeletal muscle is the biological actuator for almost all movements in animals and humans. However, under various neurological conditions, the communication pathways between the central nervous system and neuromuscular components...

Liver Danger Signal Triggers TREM2+ Macrophage-Mediated MS4A7-Dependent Inflammasome Activation Driving Steatohepatitis Background and Research Motivation In recent years, with the increasing incidence of metabolic dysfunction-associated steatohepatitis (MASH), its pathological mechanisms have garnered significant attention. MASH, formerly known as...

Simultaneously Recording Up to a Million Neurons’ Cortical Dynamics Reveals Unbounded Scaling of Neuronal Quantity and Dimensionality Summary This scientific report titled “Simultaneously Recording Up to a Million Neurons’ Cortical Dynamics Reveals Unbounded Scaling of Neuronal Quantity and Dimensionality,” published in the journal Neuron (Volume 1...