Identification of Retinal Oligomeric, Citrullinated, and Other Tau Isoforms in Early and Advanced AD and Relations to Disease Status

Medicine, Medical Laboratory Science, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry,
retinal biomarkers   tauopathy   frontotemporal lobar dementia   dementia with Lewy bodies   neurodegenerative diseases  

Research Report on Abnormal Tau Proteins in the Retina of Alzheimer’s Disease Patients Introduction Alzheimer’s disease (AD) is the primary cause of dementia in the elderly population worldwide. The pathological features of AD include the deposition of amyloid beta-protein (Aβ) and the aggregation of abnormal microtubule-associated tau proteins in ...

DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: a cross-comparative investigation

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Parkinsonian disorders   Multiple system atrophy   Parkinson’s disease   Progressive supranuclear palsy   DNA methylation   EWAS   WGCNA  

Cross-Comparative Study of DNA Methylation Patterns in the Frontal Lobe White Matter of Multiple System Atrophy, Parkinson’s Disease, and Progressive Supranuclear Palsy Academic Background Multiple System Atrophy (MSA) is a rare neurodegenerative disease characterized by neuronal loss and gliosis, accompanied by glial cytoplasmic inclusions (GCIs) ...

Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Alzheimer’s disease   Down syndrome   Aβ peptides   cerebral amyloid angiopathy   mass spectrometry   neuropathology  

Background Introduction Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by the death of neurons in the brain. Its main pathological features include extracellular β-amyloid plaques and intracellular neurofibrillary tangles (NFTs). β-amyloid plaques are primarily composed of aggregated Amyloid beta peptides (Aβ). A...

Sex Differences in the Extent of Acute Axonal Pathologies After Experimental Concussion

Medicine, Medical Laboratory Science, Neurology, Neurosurgery, Medical Imaging,
concussion   sex difference   diffuse axonal injury   amyloid precursor protein   voltage-gated sodium channel   axon ultrastructure  

Gender Differences in Acute Axonal Pathology Following Experimental Concussion Academic Background Each year, approximately 50 million people worldwide suffer from concussions, also known as mild traumatic brain injuries (TBI). However, for more than 15% of patients, this “mild” brain injury can lead to lasting neurocognitive dysfunction. The exist...

Regorafenib in Patients with Solid Tumors: Results from the TAPUR Study

Chemistry, Medicinal Chemistry, Medicine, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
Regorafenib   BRAF alterations   tumors   antitumor activity   TAPUR study  

The Use of Regorafenib in Patients with BRAF-Mutant Solid Tumors: A Summary of Results from the TAPUR Study Background Introduction The BRAF gene belongs to the cytoplasmic serine/threonine kinase family and regulates cell proliferation and survival by activating the mitogen-activated protein kinase signaling pathway (MAPK). BRAF mutations can lead...