Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-positive breast cancer risk

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry, Microbiology,
breast microbiome   endocrine-targeting therapies   breast cancer risk   probiotics   tissue metabolism   tumorigenesis   estrogen receptor  

Exploring the Impact of Endocrine-Targeting Therapies on Breast Microbiota and Their Potential in Breast Cancer Prevention and Treatment Breast cancer is one of the most commonly diagnosed types of cancer in women. Despite significant advancements in diagnosis and treatment, the mortality rate remains high, with over 40,000 deaths annually in the U...

The Direct and Indirect Inhibition of Proinflammatory Adipose Tissue Macrophages by Acarbose in Diet-Induced Obesity

Medicine, Rheumatology and Immunology, Endocrinology, Gastroenterology, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology,
Acarbose   Proinflammatory macrophages   Obesity   Gut microbiota   Immune regulation   Insulin resistance   Inflammation  

Exploring the Direct and Indirect Immunomodulatory Effects of Acarbose on Obesity-Associated Chronic Inflammation Academic Background With the global prevalence of obesity, related metabolic syndromes such as insulin resistance (IR), type 2 diabetes, cardiovascular diseases, and fatty liver disease have become major threats to human health. These c...

Early-Life Malnutrition Exposure Associated with Higher Osteoporosis Risk in Adulthood: A Large-Scale Cross-Sectional Study

Medicine, Orthopedics, Geriatrics, Endocrinology,
bone mineral density   cross-sectional study   malnutrition exposure   osteoporosis   fracture risk   early-life nutrition   bone health  

Early Malnutrition and the Risk of Osteoporosis in Adulthood: A Large-Scale Cross-Sectional Study Academic Background Osteoporosis is a chronic, systemic metabolic bone disease characterized by reduced bone density and deterioration of bone microstructure, leading to a significantly increased risk of fractures. Globally, approximately 9 million fra...

Adverse Complications of Cervical Spinal Fusion in Patients with Different Types of Diabetes Mellitus: A Retrospective Nationwide Inpatient Sample Database Cross-Sectional Study

Medicine, Orthopedics, Endocrinology,
cervical fusion   nationwide inpatient sample   postoperative complications   type I diabetes mellitus   type II diabetes mellitus  

Postoperative Complications of Cervical Spinal Fusion in Diabetic Patients: A Retrospective Study Background Diabetes Mellitus (DM) is a globally prevalent chronic condition that significantly impacts surgical outcomes, particularly in spine surgery. Diabetic patients face a higher risk of postoperative complications. However, over the past decade,...

Observational Cohort Study on Safety and Efficacy of Robotic Thyroidectomy with Super-Meticulous Capsular Dissection versus Open Surgery for Thyroid Cancer: Postoperative Dynamic Risk Assessment of Radioactive Iodine Therapy

Medicine, Endocrinology, Oncology,
131I-WBS   hypoparathyroidism   radioactive iodine   robotic thyroidectomy   thyroid cancer  

Comparative Study of Robotic-Assisted Thyroidectomy versus Traditional Open Surgery in Thyroid Cancer Treatment Academic Background The incidence of thyroid cancer has been increasing annually, with differentiated thyroid carcinoma (DTC) accounting for over 90% of all thyroid cancer cases. Currently, the standard treatment for DTC includes surgical...

Phosphatidylinositol Promotes the Proliferation and Invasion of Pituitary Adenoma Cells by Regulating POU1F1 Expression

Medicine, Endocrinology, Oncology, Life Sciences, Biochemistry,
phosphatidylinositol   pituitary adenoma   POU1F1   metabolomics   proteomics   cell invasion   AKT/ERK signaling pathway  

Phosphatidylinositol Promotes Pituitary Adenoma Cell Proliferation and Invasion by Regulating POU1F1 Expression Background Pituitary adenoma (PA) is one of the most common primary intracranial tumors, accounting for approximately 15% of all intracranial tumors. Although most pituitary adenomas are benign, about 30% of them are invasive, known as in...