Pro-inflammatory and Hyperinsulinaemic Dietary Patterns are Associated with Specific Gut Microbiome Profiles: A TwinsUK Cohort Study

Medicine, Endocrinology, Gastroenterology, Life Sciences, Biochemistry, Microbiology,
pro-inflammatory diet   hyperinsulinaemic diet   gut microbiome   insulin resistance   chronic inflammation  

In recent years, the role of the gut microbiome in human health and disease has garnered significant attention. Research indicates that gut microbial dysbiosis is closely associated with various chronic diseases, such as obesity, inflammatory bowel disease, cancer, and neurodegenerative disorders. Diet, as a critical factor influencing the gut micr...

Insulin Receptors in Vascular Smooth Muscle Cells Regulate Plaque Stability of Atherosclerosis

Medicine, Endocrinology, Cardiovascular System,
insulin receptor   smooth muscle cells   atherosclerosis   thrombospondin 1   inflammation   apoptosis   extracellular matrix  

Research Background Cardiovascular diseases (CVD) are one of the leading causes of death worldwide, particularly among patients with diabetes and insulin resistance, where the risk of CVD is significantly elevated. Although the prognosis for diabetic patients has improved in recent years, their CVD-related mortality rate remains 2 to 7 times higher...

Fibroblast-Specific TGF-β Signaling Mediates Cardiac Dysfunction, Fibrosis, and Hypertrophy in Obese Diabetic Mice

Medicine, Endocrinology, Cardiovascular System,
Diabetic cardiomyopathy   TGF-β   Fibrosis   Heart failure   Hypertrophy  

New Mechanism of Diabetic Cardiomyopathy: The Role of Fibroblast-Specific TGF-β/Smad3 Signaling Pathway Research Background Diabetes is a significant risk factor for cardiovascular diseases and heart failure (HF) globally. Diabetic patients not only face risks of macrovascular complications such as hypertension and atherosclerosis but are also pron...

TRIM21-Mediated Ubiquitination and Phosphorylation of ERK1/2 Promotes Cell Proliferation and Drug Resistance in Pituitary Adenomas

Medicine, Endocrinology, Neurology, Neurosurgery, Oncology,
TRIM21   ERK1/2   pituitary adenomas   cell proliferation   drug resistance   ubiquitination   phosphorylation  

Academic Background Pituitary adenomas (PAs) are common intracranial tumors with complex pathogenesis, often accompanied by abnormal hormone secretion. Although various treatments, such as dopamine agonists (DAs), are currently available, some patients exhibit drug resistance, leading to suboptimal therapeutic outcomes. Therefore, identifying new t...

Reduced-Energy Diet in Women with Gestational Diabetes: The Dietary Intervention in Gestational Diabetes DIGEST Randomized Clinical Trial

Medicine, Obstetrics and Gynecology, Endocrinology,
Gestational Diabetes   Reduced-Energy Diet   Randomized Clinical Trial   Weight Management   Perinatal Outcomes  

Research Report on Low-Energy Diet Intervention in Gestational Diabetes Academic Background Gestational Diabetes Mellitus (GDM) is a form of diabetes diagnosed for the first time during pregnancy, with a global incidence rate of approximately 6-15%. GDM not only increases the risk of short-term complications for both mothers and fetuses, such as la...

Independent effects of the human circadian system and sleep/ eating cycles on caloric intake in adolescents vary by weight status

Medicine, Pediatrics, Endocrinology, Life Sciences, Biochemistry, Biophysics,
 

The Impact of Circadian Rhythms and Behavioral Cycles on Caloric Intake in Adolescents Varies by Weight Status Academic Background The prevalence of obesity continues to rise globally, particularly among adolescents, increasing the risk of various chronic diseases such as type 2 diabetes, hypertension, and cardiovascular disorders. While previous s...