Independent effects of the human circadian system and sleep/ eating cycles on caloric intake in adolescents vary by weight status

Medicine, Pediatrics, Endocrinology, Life Sciences, Biochemistry, Biophysics,
 

The Impact of Circadian Rhythms and Behavioral Cycles on Caloric Intake in Adolescents Varies by Weight Status Academic Background The prevalence of obesity continues to rise globally, particularly among adolescents, increasing the risk of various chronic diseases such as type 2 diabetes, hypertension, and cardiovascular disorders. While previous s...

ATP-Sensitive Potassium Channels Alter Glycolytic Flux to Modulate Cortical Activity and Sleep

Medicine, Endocrinology, Neurology, Life Sciences, Biophysics,
ATP-sensitive potassium channels   glycolytic flux   sleep/wake   cortical activity   metabolic sensors  

KATP Channels Modulate Cortical Activity and Sleep by Regulating Glycolytic Flux Academic Background Glucose serves not only as the primary energy source for the brain but also as a biosynthetic substrate for neurotransmitter synthesis. Changes in glycolytic flux can alter neurotransmitter synthesis, thereby modulating cortical electroencephalograp...

A Hormone-to-Neuropeptide Pathway Inhibits Sexual Receptivity in Immature Drosophila Females

Medicine, Endocrinology, Neurology, Life Sciences, Cell Biology, Genetics,
sexual transition   female receptivity   neuropeptide   ecdysone   Drosophila  

Study on Hormone-Neuropeptide Pathway Inhibiting Sexual Receptivity in Immature Drosophila Females Academic Background Sexual maturation is a critical developmental event in the transition from juvenile to adult, accompanied by multiple physiological and behavioral changes. In Drosophila, the process of transition from an asexual state to sexual ma...

Estrogen Deficiency Alters Vascularization and Mineralization Dynamics: Insight from a Novel 3-D Humanized and Vascularized Bone Organoid Model

Medicine, Orthopedics, Endocrinology, Life Sciences, Bioengineering,
osteoporosis   vascularization   mineralization   3D model   estrogen deficiency  

The Impact of Estrogen Deficiency on Vascularization and Mineralization Dynamics—Insights from a Novel 3D Humanized and Vascularized Bone Organoid Model Academic Background Osteoporosis is a common bone disease, particularly prevalent among postmenopausal women. Osteoporosis not only manifests as a reduction in bone mass but also involves changes i...

Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances

Medicine, Geriatrics, Endocrinology, Neurology,
ketones   brain-derived neurotrophic factor   cognitive function   insulin resistance   Alzheimer's disease  

Effects of Exogenous β-Hydroxybutyrate on BDNF Signaling, Cognition, and Amyloid Precursor Protein Processing in Humans with Type 2 Diabetes and Insulin-Resistant Rodents Academic Background Patients with type 2 diabetes (T2D) have a significantly increased risk of developing neurodegenerative diseases, such as Alzheimer’s disease (AD), later in li...

Gut-Kidney Interaction Reinforces Dapagliflozin-Mediated Alleviation in Diabetic Nephropathy

Medicine, Endocrinology, Nephrology, Life Sciences, Biochemistry, Immunology,
Dapagliflozin   Diabetic Nephropathy   Gut Microbiota   Gut-Kidney Axis   Metabolites  

Mechanism Study of Dapagliflozin Improving Diabetic Nephropathy via the Gut-Kidney Axis Academic Background Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes, with approximately 40% of individuals with type 1 or type 2 diabetes developing DN in the advanced stages of the disease. Although clinical managemen...