Fibroblast Activation Protein-α Interacts with CXCL12 to Inactivate Canonical Wnt Signaling and Regulate Osteoblast Differentiation

Medicine, Orthopedics, Basic Medical Sciences, Geriatrics, Endocrinology, Life Sciences, Cell Biology, Biochemistry,
fibroblast activation protein-α   CXCL12   Wnt/β-catenin pathway   osteoblast differentiation   adipocyte differentiation   osteoporosis   mesenchymal progenitor cells  

Academic Research Background With the global population aging rapidly, osteoporosis has gradually become a major disease threatening public health. Characterized by reduced bone mass and deterioration of bone microarchitecture, osteoporosis significantly increases the risk of fractures, severely impacts the quality of life of the elderly, and bring...

Local and Distal Dynamic Changes Caused by the L205R Cushing’s Syndrome Mutant in PRKACA

Medicine, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
L205R mutation   Cushing’s syndrome   protein kinase A   molecular dynamics simulation   local spatial pattern   protein residue networks  

New Insights into the Molecular Dynamics and Allosteric Network Regulation Mechanisms of the Common Cushing’s Syndrome Mutation L205R in Protein Kinase A: Interpreting the Latest Original Research from PNAS I. Research Background and Scientific Questions Protein kinase A (PKA) is a key intracellular signal transduction molecule that regulates a var...

NF-κB-Mediated Developmental Delay Extends Lifespan in Drosophila

Medicine, Rheumatology and Immunology, Endocrinology, Life Sciences, Cell Biology, Immunology, Genetics,
developmental delay   lifespan extension   NF-κB signaling   innate immunity   Drosophila  

1. Research Background Aging has long been viewed as a gradual decline in physiological function with age. However, mounting evidence indicates that developmental programs profoundly influence aging outcomes. For instance, developmental time (the time required for an organism to reach maturity) shows a significant positive correlation with adult li...

Raptin, a Sleep-Induced Hypothalamic Hormone, Suppresses Appetite and Obesity

Medicine, Endocrinology, Life Sciences, Cell Biology,
sleep   obesity   hypothalamic hormone   appetite suppression   metabolic diseases  

In modern society, sleep deficiency has become one of the major causes of metabolic diseases. Studies have shown that insufficient sleep increases energy intake, but its effects on energy expenditure remain unclear. Although some clinical research indicates that sleep-deprived populations exhibit greater energy intake, energy expenditure does not c...

Parathyroid Vascular Anatomy Using Intraoperative Mapping Angiography: The Paratlas Study

Medicine, Endocrinology,
parathyroid   vascular anatomy   thyroidectomy   vessel distribution   intraoperative mapping  

Academic Background The preservation of the parathyroid glands (PGs) during thyroidectomy is crucial, as postoperative hypoparathyroidism is a common complication of thyroid surgery, particularly after total thyroidectomy. Approximately 30%-40% of patients experience transient hypoparathyroidism, with 5%-10% developing permanent hypoparathyroidism....

Pro-inflammatory and Hyperinsulinaemic Dietary Patterns are Associated with Specific Gut Microbiome Profiles: A TwinsUK Cohort Study

Medicine, Endocrinology, Gastroenterology, Life Sciences, Biochemistry, Microbiology,
pro-inflammatory diet   hyperinsulinaemic diet   gut microbiome   insulin resistance   chronic inflammation  

In recent years, the role of the gut microbiome in human health and disease has garnered significant attention. Research indicates that gut microbial dysbiosis is closely associated with various chronic diseases, such as obesity, inflammatory bowel disease, cancer, and neurodegenerative disorders. Diet, as a critical factor influencing the gut micr...