Trend Change Analysis of Postural Balance in Parkinson’s Disease Discriminates Between Medication State

Analysis of Trend Changes in Static Balance of Parkinson’s Disease Patients to Distinguish Drug States Introduction Maintaining static body balance is crucial for daily living, which requires coordination between different body segments. Any change or decline in balance ability increases the risk of falling. Patients with Parkinson’s disease (PD) e...

Time Synchronization Between Parietal–Frontocentral Connectivity with MRCP and Gait in Post-Stroke Bipedal Tasks

Time Synchronization of Motor-Related Cortical Potentials and Parieto-Frontocentral Connectivity in Bilateral Tasks of Stroke Patients Background In stroke rehabilitation research, functional connectivity (FC), motor-related cortical potentials (MRCP), and gait activities are common metrics related to rehabilitation outcomes. Although these have be...

Wearable Biofeedback Device to Assess Gait Features and Improve Gait Pattern in People with Parkinson’s Disease: A Case Series

Wearable Biofeedback Device to Assess Gait Features and Improve Gait Pattern in People with Parkinson’s Disease: A Case Series

Application of Wearable Biofeedback Device in Gait Assessment for Parkinson’s Disease Patients: A Case Series Study Research Background Patients with Parkinson’s Disease (PD) often exhibit abnormal gait patterns, severely affecting their independence and quality of life. Gait abnormalities primarily manifest as reduced stride length, increased step...

Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body

The purpose of this paper is to explore the developmental origin, biological characteristics, and association with eye diseases of tissue-resident macrophages in the field of ophthalmology—hyalocytes. The eye is a highly specialized sensory organ that contains the retina, part of the central nervous system, as well as non-neuronal parts like the tr...

Morphotype-Specific Calcium Signaling in Human Microglia

Morphology-Specific Calcium Signaling Characteristics in Human Microglia Background and Research Objectives Microglia are the primary immune cells of the central nervous system (CNS), involved in almost all physiological and pathological processes, including development, synaptic transmission, neuroplasticity, sleep, trauma, glioblastoma, and neuro...

Microglial AKAP8L: A Key Mediator in Diabetes-Associated Cognitive Impairment via Autophagy Inhibition and Neuroinflammation Triggering

Key Mediator Akap8l in Microglia for Diabetes-Associated Cognitive Impairment: Functions via Autophagy Inhibition and Neuroinflammation Academic Background In recent years, diabetes-associated cognitive impairment (DACI) has received increasing attention. It not only poses a threat to the self-management capabilities of diabetic patients but also i...