Impact of PD1 Blockade Added to Neoadjuvant Chemoradiotherapy on Rectal Cancer Surgery: Post-Hoc Analysis of the Randomized POLARSTAR Trial

Medicine, Oncology,
PD1 blockade   neoadjuvant chemoradiotherapy   rectal cancer   surgery   POLARSTAR trial  

Background Colorectal cancer is the third most common cancer type globally, with the greatest disease burden in East Asia. In China, 47% of newly diagnosed colorectal cancers are rectal cancers, of which 70% are radiologically staged as locally advanced (stage II/III) at diagnosis. For decades, neoadjuvant chemoradiotherapy (CRT) combined with tota...

Impact of Postoperative Complications on Clinical Outcomes After Gastrectomy for Cancer: Multicentre Study

Medicine, Gastroenterology, Oncology,
gastric cancer   postoperative complications   multicentre study   clinical outcomes   anastomotic leakage   pulmonary complications   30-day mortality  

Gastric cancer is one of the most common malignant tumors worldwide, and surgical resection (gastrectomy) is the primary treatment. Although the application of minimally invasive techniques has reduced surgical trauma, the incidence of postoperative complications after gastrectomy remains high, ranging from 20% to 40%. These complications not only ...

Preoperative Stereotactic Radiotherapy to Prevent Pancreatic Fistula in High-Risk Patients Undergoing Pancreatoduodenectomy (FIBROPANC): Prospective Multicentre Phase II Single-Arm Trial

Medicine, Hepatobiliary System, Anesthesiology, Gastroenterology, Oncology,
pancreatic fistula   stereotactic radiotherapy   pancreatoduodenectomy   high-risk patients   fibrosis   safety   efficacy  

Pancreaticoduodenectomy is a common surgery for treating tumors of the pancreas and surrounding organs, but postoperative pancreatic fistula (POPF) is one of its major complications, especially in high-risk patients, where the incidence of POPF can be as high as 50%. POPF not only increases hospitalization time and medical costs but can also lead t...

Detecting Residual Disease After Neoadjuvant Chemoradiotherapy for Oesophageal Squamous Cell Carcinoma: Prospective Multicentre PRESINO Trial

Medicine, Oncology,
Oesophageal squamous cell carcinoma   Neoadjuvant chemoradiotherapy   Residual disease   Prospective study   Multicentre trial   Tumour recurrence   Liquid biopsy  

Oesophageal Squamous Cell Carcinoma (OSCC) is one of the most common malignant tumours globally, with a particularly high incidence in East Asia. Neoadjuvant Chemoradiotherapy (NCRT) is the standard treatment for locally advanced oesophageal cancer, aiming to reduce tumour volume and improve surgical resection rates. However, some patients may achi...

Carbohydrate Antigen 19-9 (CA19-9) Response After Induction FOLFIRINOX for Locally Advanced Pancreatic Cancer Identifies Patients Who May Benefit from Surgical Exploration: Multicentre, Observational Cohort Study

Medicine, Oncology,
Locally Advanced Pancreatic Cancer   CA19-9   FOLFIRINOX   Surgical Exploration   Prognostic Factors   Survival Rate  

Pancreatic cancer is a highly malignant tumor with an extremely low five-year survival rate, especially for patients with locally advanced pancreatic cancer (LAPC), who have limited treatment options and poor prognosis. LAPC is defined based on the degree of tumor contact with adjacent blood vessels and is often considered “unresectable” at diagnos...

Patient-Reported Outcomes 3 and 18 Months After Mastectomy and Immediate Prepectoral Implant-Based Breast Reconstruction in the UK PRE-BRA Prospective Multicentre Cohort Study

Medicine, Obstetrics and Gynecology, Oncology,
breast reconstruction   patient-reported outcomes   prepectoral implant   multicentre study   mastectomy  

Mastectomy is a common surgical procedure in the treatment of breast cancer, with approximately 55,000 women diagnosed with breast cancer each year in the UK, of whom up to 40% undergo mastectomy. Mastectomy has a profound impact on women’s physical and mental health, and the UK National Institute for Health and Care Excellence (NICE) recommends th...