Prospective Longitudinal Analysis of Physiologic MRI-Based Tumor Habitat Predicts Short-Term Patient Outcomes in IDH-Wildtype Glioblastoma

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
glioblastoma   tumor habitat   physiologic MRI   prognosis prediction   IDH-wildtype  

Prospective Longitudinal Analysis of Physiologic MRI-Based Tumor Habitat Predicts Short-Term Patient Outcomes in IDH-Wildtype Glioblastoma Academic Background Glioblastoma (GBM) is a highly malignant brain tumor characterized by significant intratumoral heterogeneity, which is evident not only in gene expression and histopathology but also in macro...

Neoadjuvant Nivolumab and Chemotherapy in Early Estrogen Receptor-Positive Breast Cancer: A Randomized Phase 3 Trial

Medicine, Oncology,
breast cancer   neoadjuvant chemotherapy   nivolumab   estrogen receptor-positive   randomized trial  

Neoadjuvant Nivolumab and Chemotherapy in Early Estrogen Receptor-Positive Breast Cancer Academic Background Breast cancer is one of the most common cancers among women worldwide, with estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-negative (HER2−) breast cancer accounting for the majority of cases. Although ER+/HER2−...

Pembrolizumab and Chemotherapy in High-Risk, Early-Stage, ER+/HER2− Breast Cancer: A Randomized Phase 3 Trial

Medicine, Oncology,
breast cancer   pembrolizumab   chemotherapy   randomized trial   pathological complete response  

Pembrolizumab Combined with Chemotherapy in High-Risk, Early-Stage ER+/HER2− Breast Cancer: A Randomized Phase 3 Trial Academic Background Breast cancer is one of the most common cancers among women worldwide, with estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2−) breast cancer accounting for a significant pro...

Evaluating Generalizability of Oncology Trial Results to Real-World Patients Using Machine Learning-Based Trial Emulations

Information Science, Artificial Intelligence, Medicine, Oncology,
oncology   randomized controlled trials   machine learning   generalizability   real-world data   prognostic models   survival analysis  

Evaluation of the Generalizability of Oncology Trial Results Using Machine Learning-Based Trial Emulations Academic Background Randomized Controlled Trials (RCTs) are the gold standard for evaluating the efficacy of anti-cancer drugs, but their results often cannot be directly generalized to real-world oncology patients. RCTs typically employ stric...

Clinicogenomic Landscape of Pancreatic Adenocarcinoma Identifies KRAS Mutant Dosage as Prognostic of Overall Survival

Medicine, Hepatobiliary System, Gastroenterology, Oncology,
pancreatic cancer   KRAS mutation   genomic landscape   prognostic marker   clinical study  

Clinicogenomic Landscape of Pancreatic Ductal Adenocarcinoma: The Prognostic Role of KRAS Mutation Dosage Academic Background Pancreatic ductal adenocarcinoma (PDAC), the most common histological type of pancreatic cancer, is the third leading cause of cancer-related mortality and has the lowest five-year survival rate among all cancer types. Over ...

A Multivariable Prediction Model for Invasive Pulmonary Aspergillosis in Immunocompromised Patients with Acute Respiratory Failure (IPA-GRRR-OH Score)

Medicine, Infectious Diseases, Oncology, Life Sciences, Immunology,
Invasive Pulmonary Aspergillosis   Immunocompromised   Acute Respiratory Failure   Prediction Model   Intensive Care  

A Prediction Model for Invasive Pulmonary Aspergillosis in Immunocompromised Patients with Acute Respiratory Failure Background Introduction Invasive Pulmonary Aspergillosis (IPA) is a severe opportunistic infection commonly seen in immunocompromised patients, particularly those with immune dysfunction caused by hematological malignancies, stem cel...