Comparative Analysis of Tertiary Lymphoid Structures for Predicting Survival of Colorectal Cancer: A Whole-Slide Images-Based Study

Medicine, Oncology, Life Sciences, Immunology,
colorectal cancer   tertiary lymphoid structures   digital pathology   prognosis   immune  

Colorectal Cancer (CRC) is one of the most prevalent malignancies globally, with its prognosis closely related to immune responses within the tumor microenvironment. In recent years, Tertiary Lymphoid Structures (TLS), as an essential component of the tumor microenvironment, have been associated with favorable patient outcomes. TLS are aggregates o...

Computational Insights into CRISP3 Downregulation in Cervical Cancer and Its Cervical Lineages Pattern

Medicine, Obstetrics and Gynecology, Oncology,
cervical cancer   CRISP3   biomarkers   prognosis   epigenetic treatment  

Cervical Cancer (CC) is the fourth most common malignant tumor among women worldwide, particularly in low- and middle-income countries, where its incidence and mortality rates remain high. According to statistics, there were over 600,000 new cases and more than 340,000 deaths globally in 2020. The primary cause of cervical cancer is the persistent ...

Communication Between Cancer Cell Subtypes by Exosomes Contributes to Nasopharyngeal Carcinoma Metastasis and Poor Prognosis

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
cell heterogeneity   cell communication   exosomes   metastasis   nasopharyngeal carcinoma  

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial lining of the nasopharynx, characterized by a distinct geographical distribution, particularly with high incidence rates in Southeast Asia and Southern China. Despite significant progress in NPC treatment in recent years, the prognosis for patients remains poor, esp...

Deep Learning-Based Multi-Modal Data Integration Enhancing Breast Cancer Disease-Free Survival Prediction

Information Science, Computer Science, Artificial Intelligence, Medicine, Oncology,
breast cancer   multi-modality   deep learning   pathological   disease-free survival  

Breast cancer is one of the most common malignancies among women worldwide. Although early intervention and appropriate treatment have significantly improved patient survival rates, approximately 30% of cases still experience recurrence and distant metastasis, resulting in a 5-year survival rate of less than 23%. Traditional clinical prediction met...

Depletion of Squalene Epoxidase in Synergy with Glutathione Peroxidase 4 Inhibitor RSL3 Overcomes Oxidative Stress Resistance in Lung Squamous Cell Carcinoma

Medicine, Oncology,
lung squamous cell carcinoma   squalene epoxidase   terbinafine   reactive oxygen species   ferroptosis  

Lung cancer is one of the leading causes of death worldwide, with lung squamous cell carcinoma (LUSC) being a subtype of non-small cell lung cancer (NSCLC), accounting for 20%-30% of all NSCLC cases. Despite significant advancements in lung cancer treatment in recent years, LUSC still lacks effective targeted therapies, and patients have a poor pro...

Impact of PD1 Blockade Added to Neoadjuvant Chemoradiotherapy on Rectal Cancer Surgery: Post-Hoc Analysis of the Randomized POLARSTAR Trial

Medicine, Oncology,
PD1 blockade   neoadjuvant chemoradiotherapy   rectal cancer   surgery   POLARSTAR trial  

Background Colorectal cancer is the third most common cancer type globally, with the greatest disease burden in East Asia. In China, 47% of newly diagnosed colorectal cancers are rectal cancers, of which 70% are radiologically staged as locally advanced (stage II/III) at diagnosis. For decades, neoadjuvant chemoradiotherapy (CRT) combined with tota...