Artificial Intelligence in Chemical Exchange Saturation Transfer Magnetic Resonance Imaging

Information Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging, Oncology,
Artificial Intelligence   Chemical Exchange Saturation Transfer   Magnetic Resonance Imaging   Machine Learning   Medical Image Processing  

Academic Background Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) is an advanced non-invasive imaging technique that provides detailed molecular information about living tissues. CEST MRI works by selectively saturating exchangeable protons of specific metabolites and transferring this saturation to water molecules, ...

Targeting ADAR1 with a Small Molecule for the Treatment of Prostate Cancer

Chemistry, Medicinal Chemistry, Medicine, Urology, Pharmacy, Oncology,
prostate cancer   ADAR1   small molecule inhibitor   tumor immunity   RNA editing  

Academic Background Prostate cancer (PCA) is one of the most common malignancies in men, particularly in Western countries, where it is the second leading cause of cancer-related deaths among males. Although androgen signaling therapy is effective in the initial treatment of prostate cancer, most patients eventually relapse, and there is currently ...

Microbiome Dysbiosis, Neutrophil Recruitment and Mesenchymal Transition of Mesothelial Cells Promotes Peritoneal Metastasis of Colorectal Cancer

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
microbiome dysbiosis   neutrophil recruitment   mesothelial cells   mesenchymal transition   colorectal cancer   peritoneal metastasis   tumor microenvironment  

Background Introduction Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with high incidence and mortality rates. According to statistics, approximately 1.87 million new cases of CRC were diagnosed globally in 2020, resulting in 915,000 deaths. Peritoneal metastasis (PM) is a common metastatic pathway of CRC, with about ...

Neutrophils Physically Interact with Tumor Cells to Form a Signaling Niche Promoting Breast Cancer Aggressiveness

Medicine, Oncology, Life Sciences,
Neutrophils   Breast Cancer   Signaling Niche   Tumor Microenvironment   Single-Cell RNA Sequencing  

Academic Background Breast cancer is one of the most common malignant tumors among women worldwide, with a complex pathogenesis involving interactions among multiple cell types and signaling pathways. In recent years, the role of the tumor microenvironment (TME) in cancer progression has gradually gained attention. Neutrophils, as an essential comp...

MediVision: Empowering Colorectal Cancer Diagnosis and Tumor Localization through Supervised Learning Classifications and Grad-CAM Visualization of Medical Colonoscopy Images

Information Science, Artificial Intelligence, Medicine, Medical Imaging, Oncology,
Colorectal Cancer   Colonoscopy   Convolutional Neural Networks   Malignant Tumors   Integrated CNN   Grad-CAM  

Academic Background Colorectal Cancer (CRC) is one of the most common cancers worldwide, particularly among individuals over the age of 50. Early detection and accurate diagnosis are crucial for improving patient survival rates. However, traditional CRC screening methods, such as colonoscopy, rely heavily on the experience and visual judgment of ph...

Odronextamab Monotherapy in Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma: Primary Efficacy and Safety Analysis in Phase 2 ELM-2 Trial

Medicine, Hematology, Oncology, Life Sciences, Immunology,
Diffuse Large B Cell Lymphoma   Relapsed/Refractory   Odronextamab   ELM-2 Trial   Safety   Efficacy   Cytokine Release Syndrome  

Academic Background Diffuse Large B Cell Lymphoma (DLBCL) is an aggressive form of B-cell non-Hodgkin lymphoma (B-NHL), accounting for approximately 30% of all non-Hodgkin lymphomas. Although first-line immunochemotherapy (e.g., R-CHOP regimen) has shown efficacy in DLBCL patients, about 30% of patients relapse or become refractory (relapsed/refrac...