5-HT Orchestrates Histone Serotonylation and Citrullination to Drive Neutrophil Extracellular Traps and Liver Metastasis

5-HT Orchestrates Histone Serotonylation and Citrullination to Drive Neutrophil Extracellular Traps and Liver Metastasis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
5-HT   histone serotonylation   citrullination   neutrophil extracellular traps   liver metastasis   neuroendocrine prostate cancer   immune microenvironment  

Mechanism Study on 5-Hydroxytryptamine Regulating Histone Modifications to Drive Liver Metastasis Academic Background Cancer metastasis is one of the leading causes of cancer patient mortality, especially visceral organ metastases such as liver metastasis (liver metastasis). Neuroendocrine tumors (NETs) are a class of highly metastatic tumors, amon...

Causal Associations Between Sleep Traits, Sleep Disorders, and Glioblastoma: A Two-Sample Bidirectional Mendelian Randomization Study

Medicine, Neurology, Neurosurgery, Oncology,
sleep traits   glioblastoma   mendelian randomization   sleep disorders   causal associations  

Causal Associations Between Sleep Traits, Sleep Disorders, and Glioblastoma: A Two-Sample Bidirectional Mendelian Randomization Study Academic Background Introduction Glioblastoma (GBM) is the most aggressive and common type of malignant brain tumor, accounting for nearly 50% of all primary brain tumors in adults. It primarily originates from astro...

Hybridization-Based Discovery of Novel Quinazoline-2-Indolinone Derivatives as Potent and Selective PI3Kα Inhibitors

Chemistry, Medicinal Chemistry, Medicine, Pharmacy, Oncology,
molecular hybridization   quinazoline   2-indolinone   PI3Kα inhibitor   non-small cell lung cancer  

Research and Development of a Novel PI3Kα Inhibitor: Molecular Hybridization Technology Leads to a Breakthrough in Lung Cancer Treatment Academic Background Cancer, particularly non-small cell lung cancer (NSCLC), is the second leading cause of death worldwide. Currently, chemotherapy is the primary treatment method, but due to its lack of targetin...

HNRNPR-mediated UPF3B mRNA Splicing Drives Hepatocellular Carcinoma Metastasis

Medicine, Hepatobiliary System, Oncology,
hepatocellular carcinoma   metastasis   splice variant   HNRNPR   UPF3B-S  

HNRNPR-Mediated UPF3B mRNA Splicing Drives Hepatocellular Carcinoma Metastasis In recent years, hepatocellular carcinoma (HCC) has become one of the leading causes of cancer-related deaths worldwide due to its highly invasive and metastatic nature. The mechanisms underlying HCC metastasis are complex, with abnormal alternative splicing (AS) playing...

NCAPD3 Promotes Diffuse Large B-Cell Lymphoma Progression Through Modulating SIRT1 Expression in an H3K9 Monomethylation-Dependent Manner

Medicine, Hematology, Oncology, Life Sciences, Immunology,
NCAPD3   chromatin conformation   SIRT1   H3K9 monomethylation   diffuse large B-cell lymphoma   transcription regulation   mitosis  

Study on the Pro-Cancer Mechanism and Application Value of NCAPD3 in Diffuse Large B-Cell Lymphoma Academic Background Diffuse large B-cell lymphoma (DLBCL) is the most common hematological malignancy, characterized by significant clinical and biological heterogeneity. Although advances in treatment have been made in recent years, a subset of patie...

Unlocking Melanoma Suppression: Insights from Plasma-Induced Potent miRNAs through PI3K-AKT-ZEB1 Axis

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Non-thermal plasma   miRNA sequencing   Differential regulation   Melanoma inhibition   PI3K-AKT-ZEB1 axis  

Study on Melanoma Suppression by Non-Thermal Atmospheric Pressure Plasma via the PI3K-AKT-ZEB1 Axis Academic Background Melanoma is the most aggressive and deadly form of skin cancer, particularly in its advanced stages, making treatment extremely challenging. Although recent advancements in targeted therapy and immunotherapy have improved patient ...