A Multivariable Prediction Model for Invasive Pulmonary Aspergillosis in Immunocompromised Patients with Acute Respiratory Failure (IPA-GRRR-OH Score)

Medicine, Infectious Diseases, Oncology, Life Sciences, Immunology,
Invasive Pulmonary Aspergillosis   Immunocompromised   Acute Respiratory Failure   Prediction Model   Intensive Care  

A Prediction Model for Invasive Pulmonary Aspergillosis in Immunocompromised Patients with Acute Respiratory Failure Background Introduction Invasive Pulmonary Aspergillosis (IPA) is a severe opportunistic infection commonly seen in immunocompromised patients, particularly those with immune dysfunction caused by hematological malignancies, stem cel...

Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
glioblastoma   cellular plasticity   forskolin   differentiation therapy   radiotherapy  

Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation Academic Background Glioblastoma (GBM) is one of the deadliest brain cancers in adults, with a median survival period of only 15 to 18 months for patients. Although surgery combined with chemoradiotherapy can delay disease progression, these treatments ...

Modeling Tissue Electroporation: Effects of Electric Field Direction Change Between Pulses and Increased Conductivity in Post-IRE Regions

Engineering, Medicine, Oncology, Life Sciences, Bioengineering,
Irreversible Electroporation   Electric Field Direction Change   Post-IRE Regions   Conductivity   Numerical Model   Tumor Ablation   Treatment Planning  

Tissue Electroporation Modeling Research Background Introduction Electroporation is a phenomenon that occurs when cell membranes are exposed to short electrical pulses, increasing the permeability of the cell membrane to ions and macromolecules. Depending on the impact of electrical pulses on the cell membrane, electroporation can be classified as ...

USP35 Promotes Breast Cancer Progression by Regulating PFK-1 Ubiquitination to Mediate Glycolysis

Medicine, Oncology,
breast cancer   ubiquitination   glycolysis   PFK-1   USP35  

USP35 Promotes Breast Cancer Progression by Regulating PFK-1 Ubiquitination to Mediate Glycolysis Academic Background Breast cancer is the most common malignant tumor affecting women worldwide and remains a leading cause of cancer-related mortality among women. Despite the development of various treatment strategies for different molecular subtypes...

RFC4 Confers Radioresistance of Esophagus Squamous Cell Carcinoma through Regulating DNA Damage Response

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
RFC4   esophageal squamous cell carcinoma   radioresistance   DNA damage repair   p53 signaling pathway  

New Discovery in the Mechanism of Radioresistance in Esophageal Squamous Cell Carcinoma: The Role of the RFC4 Gene Academic Background Esophageal squamous cell carcinoma (ESCC) is one of the most common gastrointestinal malignancies in China, and radiotherapy is a crucial treatment modality. However, radioresistance in tumor cells is a major cause ...

Peripheral, Central, and Chemotherapy-Induced Neuropathic Changes in Pancreatic Cancer

Medicine, Neurology, Oncology,
pancreatic cancer   neuropathic changes   chemotherapy-induced neuropathy   neural remodeling   neuropathic pain  

Neuropathic Changes in Pancreatic Cancer Academic Background Pancreatic cancer is one of the most lethal cancers today, characterized by late diagnosis and high aggressiveness. Despite some progress in diagnosis and treatment in recent years, the five-year survival rate for pancreatic cancer remains extremely low, at only around 12%. The pathogenes...