Early Mechanisms of Left-Right Symmetry Breaking in Amniote Gastrulation

Early Origin of Left-Right Asymmetry in Embryonic Development Academic Background Bilateral symmetry is a widely prevalent body structure feature in the animal kingdom. However, while vertebrates exhibit bilateral symmetry externally, their internal organs display left-right (LR) asymmetry. This asymmetry plays a crucial role during embryonic devel...

Contextual Neural Dynamics during Time Perception in the Primate Ventral Premotor Cortex

Neural Dynamics of Time Perception in the Ventral Premotor Cortex Academic Background Time perception is one of the central questions in neuroscience, particularly how the brain encodes time information as cognitive demands change. Time can be categorized as “long” or “short,” or it can be precisely represented as continuous intervals. The ventral ...

Active Vision in Freely Moving Marmosets Using Head-Mounted Eye Tracking

Study of Visual Behavior in Freely Moving Primates: Development and Application of an Innovative Eye-Tracking System Academic Background The visual system is one of the most extensively studied areas within the primate nervous system, particularly concerning the mechanisms of visual pathways in the cerebral cortex. However, current research on how ...

Evidence for Domain-General Arousal from Semantic and Neuroimaging Meta-Analyses Reconciles Opposing Views on Arousal

Neuroscientific Research Report on “Domain-General Arousal” Academic Background Arousal is a core concept in neuroscience, referring to fluctuations in brain and body states that underpin motivated behavior. Despite the widespread use of the term “arousal,” its definition has remained ambiguous, with differing interpretations in various textbooks. ...

Cataract-Prone Variants of γD-Crystallin Populate a Conformation with a Partially Unfolded N-Terminal Domain under Native Conditions

Study on Partially Unfolded Intermediate of γD-Crystallin Variants under Native Conditions Academic Background Human γD-crystallin is a structural protein in the eye lens, crucial for maintaining its transparency and stability. It must remain folded throughout an individual’s lifetime to avoid aggregation and protein deposition, thus preventing cat...

Human MAIT Cell Response Profiles Biased Toward IL-17 or IL-10 Are Distinct Effector States Directed by the Cytokine Milieu

Functional Plasticity of Human MAIT Cells and Their Role in Immune Regulation Academic Background Mucosal-Associated Invariant T cells (MAIT cells) are a type of unconventional T lymphocyte found abundantly in healthy humans, especially in mucosal tissues. MAIT cells exhibit innate-like characteristics, rapidly recognizing antigens derived from mic...

Spatial Patterning Analysis of Cellular Ensembles (SPACE) Detects Complex Spatial Organization at the Cell and Tissue Levels

Spatial Patterning Analysis of Cellular Ensembles (SPACE): Revealing Complex Spatial Patterns in Biological Tissues Academic Background The function of biological tissues depends on the interactions of cells, molecules, and structures in three-dimensional space. Understanding these spatial organization patterns can provide new insights into patholo...

Quantifying the Impact of Air Pollution from Coal-Fired Electricity Generation on Crop Productivity in India

Impact of Air Pollution from Coal-Fired Electricity Generation on Crop Productivity in India Academic Background India is one of the world’s largest agricultural producers and also one of the most air-polluted countries. Coal-fired power generation is a primary source of electricity supply in India, but the air pollutants it generates, especially n...

Fixational Eye Movements as Active Sensation for High Visual Acuity

Fixational Eye Movements as Active Sensation for High Visual Acuity Academic Background Human visual perception is a complex process, especially when we attempt to maintain stable gaze. Even then, the eyes still produce small involuntary movements known as fixational eye movements (FEM). These FEM typically include drifts and microsaccades. Previou...

Intracranial Substrates of Meditation-Induced Neuromodulation in the Amygdala and Hippocampus

Study on the Neuroregulatory Effects of Meditation: A Case Study of Loving-Kindness Meditation Academic Background Meditation, as a mental training technique, has long been believed to regulate emotions and enhance mental health. Specifically, Loving-Kindness Meditation (LKM), which focuses on cultivating positive emotions towards oneself and other...