GL-MCM: Global and Local Maximum Concept Matching for Zero-Shot Out-of-Distribution Detection Research Background and Problem Statement In real-world applications, machine learning models often face changes in data distribution, such as the emergence of new categories. This phenomenon is known as “Out-of-Distribution Detection (OOD).” To ensure the...
Lidar-Guided Geometric Pretraining Enhances Performance of Vision-Centric 3D Object Detection Background Introduction In recent years, multi-camera 3D object detection has garnered significant attention in the field of autonomous driving. However, vision-based methods still face challenges in precisely extracting geometric information from RGB imag...
An Experimental Study on Exploring Strong Lightweight Vision Transformers via Masked Image Modeling Pre-training Academic Background In recent years, self-supervised learning (SSL) has made significant progress in the field of computer vision. In particular, the successful application of masked image modeling (MIM) pre-training methods on large-sca...
Functional Segregation of Dopaminergic Neural Circuits and Their Developmental Mechanisms Academic Background Dopamine is a crucial neurotransmitter in the brain, regulating various physiological functions, including motor control, emotional regulation, motivation, learning, and memory. Dopaminergic neurons are primarily located in the midbrain, an...
Academic Background In the mammalian neocortex, somatostatin (SST)-expressing neurons are a major class of inhibitory interneurons that exhibit diversity in electrophysiology and morphology, and are involved in various cognitive functions such as learning, memory, and sensory processing. However, despite extensive research on the diversity of SST n...
Neuropathic Changes in Pancreatic Cancer Academic Background Pancreatic cancer is one of the most lethal cancers today, characterized by late diagnosis and high aggressiveness. Despite some progress in diagnosis and treatment in recent years, the five-year survival rate for pancreatic cancer remains extremely low, at only around 12%. The pathogenes...
Academic Background Frontotemporal Dementia (FTD) is a group of progressive neurodegenerative diseases characterized primarily by behavioral changes, language impairment, or motor dysfunction. Although the incidence of FTD is lower than that of Alzheimer’s Disease (AD), it remains one of the leading causes of early-onset dementia. The molecular bas...
Academic Background Chronic autoimmune diseases are typically triggered by a combination of genetic predisposition and environmental factors, with complex and incompletely understood mechanisms. In many cases, these diseases require lifelong immunosuppressive treatments, imposing a heavy burden on patients. Recent research has found that gut microb...
New Method for Early Detection of Pancreatic Cancer—A Protease-Activated Nanosensor Assay Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths worldwide. Due to its nonspecific early symptoms, most patients are diagnosed at advanced stages, resulting in limited treatment options and poor prognosis...
Therapeutic Potential of ASO-Mediated MSH3 Suppression in Huntington’s Disease Academic Background Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal expansion of the CAG repeat sequence in the huntingtin gene (HTT). This expanded CAG repeat continues to expand somatically over time, driving the onset and progression of th...