Subtype-Specific Differences in Metabolic Profiles of Pancreatic Cancer Tumor Organoids

Medicine, Oncology, Life Sciences, Biochemistry,
Pancreatic cancer   Metabolic reprogramming   Glycolysis   Oxidative phosphorylation   Tumor organoids   Subtype-specific   Mitochondrial pyruvate carrier  

Metabolic Characteristics of Pancreatic Ductal Adenocarcinoma (PDAC) Subtypes Background Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive cancer with a five-year survival rate of only 13%, making it the third leading cause of cancer-related deaths. The aggressiveness and chemoresistance of PDAC are closely linked to its complex metabo...

Metabolism of Primary High-Grade Serous Ovarian Carcinoma (HGSOC) Cells under Limited Glutamine or Glucose Availability

Medicine, Obstetrics and Gynecology, Oncology,
High-Grade Serous Ovarian Carcinoma   Metabolic Flexibility   Oxidative Phosphorylation   Endoplasmic Reticulum Stress   Chemotherapy Resistance  

Metabolism of High-Grade Serous Ovarian Carcinoma (HGSOC) Cells Academic Background High-Grade Serous Ovarian Carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer. Most patients are diagnosed at stage III or IV, with a 5-year survival rate ranging from 20% to 40%. Treatment for HGSOC typically involves surgical r...

PAF1/HIF1α Axis Rewires Glycolytic Metabolism to Fuel Aggressiveness of Pancreatic Cancer

Medicine, Oncology, Life Sciences, Biochemistry,
Pancreatic Cancer   Metabolic Reprogramming   Aerobic Glycolysis   PAF1/HIF1α Axis   Lactate Dehydrogenase A  

PAF1/HIF1α Axis Promotes Pancreatic Cancer Aggressiveness by Regulating Glycolytic Metabolism Background Pancreatic cancer (PC) is a highly aggressive malignant tumor, with pancreatic ductal adenocarcinoma (PDAC) being the most common type. Despite significant advancements in cancer treatment in recent years, the 5-year survival rate for pancreatic...

Silencing of STEAP3 Suppresses Cervical Cancer Cell Proliferation and Migration via JAK/STAT3 Signaling Pathway

Medicine, Oncology,
STEAP3   cervical cancer   JAK/STAT3 signaling pathway   cell proliferation   cell migration   DNA methylation   iron metabolism  

The Role and Mechanism of STEAP3 in Cervical Cancer Background Cervical cancer (CC) is the fourth most common cancer among women globally, with approximately 600,000 new cases and 300,000 deaths annually. Although the five-year survival rate for early-stage cervical cancer patients exceeds 85% through treatments such as surgery, radiotherapy, and c...

Phosphatidylinositol Promotes the Proliferation and Invasion of Pituitary Adenoma Cells by Regulating POU1F1 Expression

Medicine, Endocrinology, Oncology, Life Sciences, Biochemistry,
phosphatidylinositol   pituitary adenoma   POU1F1   metabolomics   proteomics   cell invasion   AKT/ERK signaling pathway  

Phosphatidylinositol Promotes Pituitary Adenoma Cell Proliferation and Invasion by Regulating POU1F1 Expression Background Pituitary adenoma (PA) is one of the most common primary intracranial tumors, accounting for approximately 15% of all intracranial tumors. Although most pituitary adenomas are benign, about 30% of them are invasive, known as in...

Similar Deficiencies, Different Outcomes: Succinate Dehydrogenase Loss in Adrenal Medulla vs. Fibroblast Cell Culture Models of Paraganglioma

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Succinate Dehydrogenase   Paraganglioma   Adrenal Medulla   Fibroblasts   Metabolism   Tumorigenesis   Hypoxic Signaling  

Different Manifestations of SDH Loss in Adrenal Medulla vs. Fibroblast Models Background Introduction Succinate dehydrogenase (SDH) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle and electron transport chain, responsible for oxidizing succinate to fumarate and participating in electron transfer. SDH consists of four subunits (S...