Similar Deficiencies, Different Outcomes: Succinate Dehydrogenase Loss in Adrenal Medulla vs. Fibroblast Cell Culture Models of Paraganglioma

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Succinate Dehydrogenase   Paraganglioma   Adrenal Medulla   Fibroblasts   Metabolism   Tumorigenesis   Hypoxic Signaling  

Different Manifestations of SDH Loss in Adrenal Medulla vs. Fibroblast Models Background Introduction Succinate dehydrogenase (SDH) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle and electron transport chain, responsible for oxidizing succinate to fumarate and participating in electron transfer. SDH consists of four subunits (S...

A Whole Food, Plant-Based Diet Reduces Amino Acid Levels in Patients with Metastatic Breast Cancer

Medicine, Oncology, Life Sciences, Biochemistry,
whole food plant-based diet   amino acids   cancer   diet   fat   carbohydrate   protein   fiber  

The Impact of a Whole Food, Plant-Based Diet on Amino Acid Levels in Patients with Metastatic Breast Cancer Research Background The growth and survival of cancer cells depend on significant metabolic demands, particularly for amino acids. Tumors meet these demands by acquiring amino acids from the surrounding microenvironment, and dietary amino aci...

PFKFB3-Dependent Redox Homeostasis and DNA Repair Support Cell Survival Under EGFR-TKIs in Non-Small Cell Lung Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
Non-small cell lung carcinoma   EGFR   PFKFB3   Oxidative stress   DNA repair   ROS-dependent cell death   Metabolic rewiring  

The Role of PFKFB3 in EGFR-TKIs Tolerance in Non-Small Cell Lung Cancer Background Introduction Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) mutations are relatively common in NSCLC, accounting for approximately 15-30% of cases. Although EGFR tyrosine kin...

TDO2 Inhibition Counters Benzo[a]pyrene-Induced Immune Evasion and Suppresses Tumorigenesis in Lung Adenocarcinoma

Medicine, Oncology, Life Sciences, Biochemistry, Immunology,
Benzo[a]pyrene   TDO2   Immune evasion   Lung adenocarcinoma   Tryptophan metabolism   PD-L1   ICOSL  

The Role of TDO2 Inhibition in Lung Cancer Immune Evasion Background Introduction Lung cancer is one of the leading causes of cancer-related deaths worldwide, with smoking recognized as a primary cause of its occurrence. Cigarette smoke contains numerous carcinogens, among which benzo[a]pyrene (BAP), a polycyclic aromatic hydrocarbon, has been show...

Glutaminolysis is Associated with Mitochondrial Pathway Activation and Can Be Therapeutically Targeted in Glioblastoma

Medicine, Oncology, Life Sciences, Biochemistry,
Glioblastoma   Glutaminolysis   Mitochondria   Metabolic changes   Therapeutic target  

The Relationship Between Metabolic Reprogramming and Glutamine Metabolism in Glioblastoma Background Introduction Glioblastoma is a highly aggressive primary brain tumor with a very poor prognosis. Although current standard treatments include surgery, radiotherapy, and chemotherapy, there is no cure for the disease. In recent years, metabolic repro...

Complete Inhibition of Liver Acetyl-CoA Carboxylase Activity Exacerbates Liver Tumorigenesis in Mice Treated with Diethylnitrosamine

Medicine, Hepatobiliary System, Oncology, Life Sciences, Biochemistry,
liver cancer   de novo lipogenesis   acetyl-CoA carboxylase   tumorigenesis   diethylnitrosamine   metabolic pathway   mouse model  

Inhibition of Liver Acetyl-CoA Carboxylase (ACC) Activity Exacerbates Liver Tumorigenesis in Mice Academic Background Liver cancer is the sixth most common cancer globally and the third leading cause of cancer-related mortality. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. In recent years, the burden of liver canc...