A Neural Basis of Choking Under Pressure

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
neural activity   pressure   motor cortex   reward signals   movement preparation  

The Neural Basis of Underperformance Under Pressure: An Analysis of the Interaction Between Reward Signals and Motor Preparation in Primate Brains Research Background “Choking under pressure” refers to situations where individuals fail to perform as expected due to the stress of important moments, as often seen with professional athletes during cri...

Synaptic Neoteny of Human Cortical Neurons Requires Species-Specific Balancing of SRGAP2-SYNGAP1

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry,
human-specific genes   synaptic neoteny   SRGAP2   SYNGAP1   autism spectrum disorder  

I. Research Background: Neoteny in Human Brain Development and Neurodevelopmental Disorders One of the remarkable features of human brain development is the slow developmental pace of cortical neurons. Compared to other mammals, especially non-human primates, the developmental process of human cortical neurons can last for several years. This neote...

A Bimodal Taxonomy of Adult Human Brain Sulcal Morphology Related to Timing of Fetal Sulcation and Trans-Sulcal Gene Expression Gradients

A Bimodal Taxonomy of Adult Human Brain Sulcal Morphology Related to Timing of Fetal Sulcation and Trans-Sulcal Gene Expression Gradients

Medicine, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry, Genetics,
brain sulci   sulcal morphology   fetal development   gene expression   morphology  

Research Background and Objectives This study focuses on the complex morphological features of the adult cerebral cortex sulci, specifically the classification of linear and complex morphologies of brain sulci and their developmental mechanisms. The sulci are groove structures on the surface of the cerebral cortex, corresponding to different geneti...

Gut-Induced Alpha-Synuclein and Tau Propagation Initiate Parkinson’s and Alzheimer’s Disease Co-Pathology and Behavior Impairments

Medicine, Neurology, Gastroenterology, Medical Imaging, Life Sciences, Cell Biology,
alpha-synuclein   tau protein   Parkinson's disease   Alzheimer's disease   behavioral impairments   gut-brain axis   neurodegeneration  

Gastrointestinal-Induced Spread of α-Synuclein and Tau Proteins Triggers Comorbid Pathology and Behavioral Impairments in Parkinson’s and Alzheimer’s Diseases Background Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are two common neurodegenerative disorders, caused by the aggregation of α-synuclein (a-syn) and Tau protein in the brain, res...

Ferroptosis Triggered by Spliceosomal GTPase EFTUD2 Deficiency Leads to Purkinje Cell Degeneration

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
spliceosome   EFTUD2   ferroptosis   Purkinje cells   neurodegeneration   cerebellar development  

Depletion of EFTUD2 Triggers Ferroptosis-Induced Degeneration of Cerebellar Purkinje Cells Background and Motivation The cerebellum plays a crucial role in motor coordination and higher cognitive functions, with the health of cerebellar Purkinje cells (PCs) being essential for maintaining cerebellar function. Gene regulation based on alternative sp...

Disruption of Nuclear Speckle Integrity Dysregulates RNA Splicing in C9orf72-FTD/ALS

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
nuclear speckles   RNA splicing   C9orf72   FTD   ALS  

Disruption of Nucleolar Integrity and Dysregulation of RNA Splicing in C9orf72-FTD/ALS Background and Research Motivation The hexanucleotide repeat expansion (GGGGCC)n in the C9orf72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Studies have shown that these repeat sequences not only...