Reversible Regulation of Retinal and Peripheral Nerve Function: Physiological Study of Serine and Glycine Background and Research Motivation Macular Telangiectasia Type 2 (Mactel) is an age-related retinal disease characterized by central vision loss. The molecular etiology of this disease is complex and is primarily associated with the metabolism ...
Obesity Aggravates Female Central Nervous System Autoimmune Diseases Through Sex-Specific Interferon Signaling In recent years, the rising incidence of central nervous system (CNS) autoimmune diseases in females has garnered widespread attention. Obesity, as a potential environmental risk factor, has gradually become a research hotspot. The latest ...
The Loss of β-arrestin 2 in Hepatic Macrophages Alleviates Metabolic Dysfunction-associated Steatohepatitis — Through Metabolic Reprogramming of Macrophages Background and Motivation Metabolic dysfunction-associated fatty liver disease (MASLD) is a globally prevalent health issue, affecting approximately 25% of the population. This disease includes...
The Role of m6A mRNA Methylation in Adipose Tissue: A Breakthrough Discovery of Cross-Organ Prostaglandin Signaling Axis in Insulin Sensitivity Regulation Research Background and Motivation In recent years, the potential role of brown adipose tissue (BAT) in human metabolic regulation has attracted widespread attention. Known for its thermogenic pr...
Research on SGLT2 Inhibitors Alleviating MASH by Enhancing Ketogenesis to Inhibit CD8+ T Cell Activation Research Background and Problem Positioning Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has become a global health concern. Its severe stage, Metabolic Dysfunction-Associated Steatohepatitis (MASH), leads to hepatocyte damag...
IL-22 Restores Gut Homeostasis and Alleviates Diet-Induced MASLD In recent years, the incidence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has significantly increased, closely related to the widespread consumption of high-energy diets rich in sugars and fats. MASLD is not only closely linked to metabolic diseases such as ob...