Microglia-specific IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   IL-10   Neuroinflammation   Neurodegeneration   Parkinson's Disease  

Parkinson’s Disease Mouse Model: IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration As research into the pathogenesis of Parkinson’s Disease (PD) deepens, the role of neuroinflammation in PD is gradually being revealed. This study by Simone Bido and his team, published in “Science Translational Medicine”, explores the effects of t...

Different Learning Aberrations Relate to Delusion-like Beliefs with Different Contents

Medicine, Basic Medical Sciences, Psychiatry, Neurology, Clinical Psychology,
Learning Aberrations   Delusions   Prediction Error   Psychiatric Disorders   Paranoia   Cognitive Tasks  

A Study on the Correlation Between Different Learning Abnormalities and Delusional-like Beliefs of Various Contents Research Background Delusions are a major feature of psychotic disorders (such as schizophrenia, bipolar disorder, depression, and certain neurological and autoimmune diseases). Although delusions clinically manifest as fixed erroneou...

Development and Preclinical Validation of 2-Deoxy 2-[18F]Fluorocellobiose as an Aspergillus-Specific PET Tracer

Medicine, Infectious Diseases, Medical Laboratory Science, Medical Imaging, Life Sciences, Biochemistry, Immunology, Microbiology,
Aspergillus   PET tracer   2-Deoxy 2-[18F]Fluorocellobiose   Invasive fungal infections   Sugar metabolism   Radiolabeled tracer  

Academic Report The incidence of global Invasive Fungal Infections (IFIs) has increased over the past few decades, primarily affecting immunocompromised patients, and these infections are often associated with high mortality and morbidity rates. Aspergillus fumigatus is one of the most common and deadly IFI pathogens. The main obstacles to effectiv...

Acyl-CoA Binding Protein for the Experimental Treatment of Anorexia

Medicine, Psychiatry, Endocrinology, Neurology, Gastroenterology, Life Sciences, Biochemistry, Immunology,
Anorexia   Acyl-CoA Binding Protein   Diazepam Binding Inhibitor   Chronic Restraint Stress   Autophagy-dependent Secretion Pathway  

Introduction This report aims to reveal the recent research findings published by Hui Chen et al. in “Science Translational Medicine”, which explores the application of exogenous Acyl-Coenzyme A Binding Protein (ACBP) in Anorexia Nervosa. Anorexia Nervosa is a prevalent and difficult-to-treat eating disorder that primarily affects adolescents and y...

Novel Insight into Atogepant Mechanisms of Action in Migraine Prevention

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Pharmacy, Life Sciences, Cell Biology,
migraine   headache   trigeminovascular   gepants   central sensitization   pain  

New Research Reveals the Mechanism of Atogepant in Migraine Prevention Background Migraine is a common and highly disruptive neurological disorder affecting millions of people worldwide. Calcitonin Gene-Related Peptide (CGRP) is believed to play a key role in the pathophysiology of migraine. CGRP released from sensory trigeminal ganglia neurons in ...

Natural Killer Cells Promote Neutrophil Extracellular Traps and Restrain Macular Degeneration in Mice

Medicine, Basic Medical Sciences, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Immunology,
natural killer cells   neutrophil extracellular traps   macular degeneration   mouse model   immune mechanisms  

Study on Macular Degeneration Reveals Inhibitory Effect of Natural Killer Cells on Disease Progression Background Age-related Macular Degeneration (AMD) is the leading cause of irreversible blindness among the elderly globally. With an aging population, the incidence of AMD is significantly increasing. Early features of AMD include the accumulation...