Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank

Medicine, Geriatrics, Neurology, Cardiovascular System,
body composition   cardiovascular disease   neurodegenerative disease   UK Biobank   obesity  

Study on the Association# Study on the Association Between Body Composition Patterns, Cardiovascular Diseases Between, Body and Neurodegenerative Composition Disease Risks Background Neurodegenerative Patterns diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease, (PD), currently affect over Cardiovascular Diseases, and Neuro60degene...

Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry,
Parkinson's disease   brain network   α-synuclein   diffusion-weighted imaging   network resilience  

Scientific Paper News Report: Pathological Basis and Topological Properties of Structural Brain Networks in Parkinson’s Disease Patients Background and Research Objectives In Parkinson’s disease (PD), α-synuclein spreads between connected brain regions, leading to neuronal loss and brain network disruption. Using diffusion-weighted imaging (DWI), t...

Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Medicine, Medical Laboratory Science, Neurology,
antiseizure medications   clinical trials   time-to-event design   efficacy   epilepsy   safety   randomized controlled trial  

Time-to-Event Design in Clinical Trials and Efficacy of Anti-Epileptic Drugs at Group and Individual Levels Background The significance of anti-epileptic drugs (ASM) in treating refractory epilepsy cannot be ignored. However, the current parallel assignment, randomized, placebo-controlled trial (RCT) designs have been in use for many years, requiri...

Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age from Blind Ultrasound Sweeps

Information Science, Artificial Intelligence, Medicine, Obstetrics and Gynecology, Medical Imaging,
integrated AI tool   gestational age estimation   diagnostic accuracy   blind ultrasound sweeps   low-resource settings   pregnancy care   obstetrical sonography  

Diagnostic Accuracy of AI Tools for Estimating Gestational Age Based on Blind Ultrasound Scanning Background Accurate estimation of gestational age (GA) is the foundation of good prenatal care, typically achieved through ultrasound examinations. However, many low-resource areas lack sufficient ultrasound equipment, making accurate GA estimation cha...

Electroencephalography-Guided Anesthesia and Delirium in Older Adults after Cardiac Surgery

Medicine, Psychiatry, Geriatrics, Anesthesiology, Neurology, Cardiovascular System,
Electroencephalography   Anesthesia   Older Adults   Cardiac Surgery   Delirium  

EEG-Guided Anesthesia and Delirium in Elderly Patients After Cardiac Surgery Research Background Delirium is a common postoperative complication in elderly patients, particularly after cardiac surgery. Delirium not only leads to cognitive decline but also increases hospitalization time and medical costs. Current preventive measures are limited in e...

Efficacy and Safety of Pamrevlumab in Idiopathic Pulmonary Fibrosis: The Zephyrus-1 Randomized Clinical Trial

Medicine, Respiratory System,
Pamrevlumab   Idiopathic Pulmonary Fibrosis   Phase 3 Trial   Lung Function   Antifibrotic Therapy  

Pamrevlumab Treatment for Idiopathic Pulmonary Fibrosis: The ZEPHYRUS-1 Randomized Clinical Trial Idiopathic Pulmonary Fibrosis (IPF) is a rare interstitial lung disease that typically occurs in adults over 60 years old. It is characterized by cough, breathlessness, and fatigue. This disease leads to progressive loss of lung function, decreased exe...