Whole-brain mapping of inputs and outputs of specific orbitofrontal cortical neurons in mice

Whole-brain mapping of inputs and outputs of specific orbitofrontal cortical neurons in mice

Medicine, Basic Medical Sciences, Medical Imaging,
orbitofrontal cortex   projection specific   rabies virus retrograde tracing   anterograde transsynaptic virus tracing   inhibitory neurons  

Whole-Brain Mapping of Specific Orbitofrontal Cortex Neuron Inputs and Outputs in Mice Research on the mouse brain has always been an important topic in neuroscience, especially studies on the orbitofrontal cortex (ORB). The ORB plays a key role in reward processing, decision making, behavioral flexibility, and emotional regulation. In recent years...

Treadmill Exercise Reshapes Cortical Astrocytic and Neuronal Activity to Improve Motor Learning Deficits Under Chronic Alcohol Exposure

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology,
alcohol abuse   motor learning   dendritic spine   reactive astrocyte   cortical neurons   treadmill exercise  

Background and Research Motivation Alcohol abuse is a global health issue, affecting over 8% of the male population. Prolonged alcohol exposure can alter the homeostasis of neurons and synapses in the brain, leading to various mental disorders and cognitive deficits, especially in motor learning. Previous studies have shown that alcohol abuse cause...

Link Brain-wide Projectome to Neuronal Dynamics in the Mouse Brain

Medicine, Basic Medical Sciences, Medical Imaging, Life Sciences, Biophysics,
brain-wide projectome   neuronal dynamics   mouse   somatosensory cortex   dopaminergic neurons  

Background Introduction The brain is composed of different subtypes of neurons, which form complex neural networks through local and long-range synaptic connections. Understanding the functions of these neural networks requires knowledge of their connection patterns (projectome) and neuronal dynamics. Although advancements in mesoscale connectomics...

Thalamic Nucleus Reuniens Glutamatergic Neurons Mediate Colorectal Visceral Pain in Mice via 5-HT2B Receptors

Thalamic Nucleus Reuniens Glutamatergic Neurons Mediate Colorectal Visceral Pain in Mice via 5-HT2B Receptors

Medicine, Anesthesiology, Life Sciences, Biochemistry,
colorectal visceral pain   thalamic nucleus reuniens   neonatal maternal deprivation   glutamatergic neurons   5-HT2B receptors  

Thalamic Reuniens Nucleus Glutamatergic Neurons Mediated Colorectal Visceral Pain in Mice through 5-HT2B Receptors Background Irritable Bowel Syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral hypersensitivity is crucial for effectively alleviating abdominal pain in ...

Distillation of Multi-Class Cervical Lesion Cell Detection via Synthesis-Aided Pre-Training and Patch-Level Feature Alignment

Distillation of Multi-Class Cervical Lesion Cell Detection via Synthesis-Aided Pre-Training and Patch-Level Feature Alignment

Information Science, Artificial Intelligence, Medicine, Obstetrics and Gynecology,
Cervical lesion cell detection   Knowledge distillation   Image synthesis   Computer-aided diagnosis  

Distillation of Multi-Class Cervical Lesion Cell Detection via Synthesis-Aided Pre-Training and Patch-Level Feature Alignment Background and Research Significance Cervical cancer is a disease that seriously threatens the life and health of women. According to data from the International Agency for Research on Cancer (IARC), there were approximately...

Federated Learning Using Model Projection for Multi-Center Disease Diagnosis with Non-IID Data

Federated Learning Using Model Projection for Multi-Center Disease Diagnosis with Non-IID Data

Information Science, Artificial Intelligence, Medicine, Environmental and Public Health,
Federated Learning   Model Projection   Multi-Center Disease Diagnosis   Non-IID Data   Catastrophic Forgetting   Invalid Aggregation  

Federated Learning Using Model Projection for Multi-Center Disease Diagnosis Background Introduction With the rapid development of medical imaging technology, research on automated diagnostic methods has shown good performance on single-center datasets. However, these methods often find it difficult to generalize to data from other healthcare facil...