Novel Coumarins Derivatives for A. baumannii Lung Infection Developed by High-throughput Screening and Reinforcement Learning

Chemistry, Organic Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases,
A. baumannii   coumarins   lung infection   high-throughput screening   reinforcement learning   structure optimization  

Review of Research on Treatment of Lung Infections with Novel Coumarin Derivatives Background With the increasing antibiotic resistance, especially the problem of Acinetobacter baumannii’s resistance to antibiotics, researchers worldwide have begun to search for new antimicrobial agents. This Gram-negative bacterium, with its high survivability and...

Gene Expression Alterations in the Spinal Cord of SIV-Infected Macaques on Antiretroviral Therapy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
SIV   HIV   spinal cord   antiretroviral therapy   gene expression   neuropathy  

NARP Laboratory Research Reveals the Impact of SIV Infection on Spinal Cord Gene Expression Background Despite the implementation of antiretroviral therapy (ART), HIV-associated peripheral neuropathy (HIV-DSP) remains one of the most common neurological manifestations of HIV infection. Clinical symptoms of HIV-DSP include weakness, numbness, burnin...

Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN)

Medicine, Infectious Diseases, Rheumatology and Immunology, Neurology, Gastroenterology, Life Sciences, Immunology,
antibiotics   intestinal immunity   experimental autoimmune neuritis   immunomodulation   Guillain-Barré syndrome   gut microbiota  

Antibiotic-Induced Intestinal Immunomodulation Alleviates Experimental Autoimmune Neuritis (EAN) Academic Background Guillain-Barré syndrome (GBS) is an acute autoimmune disease that causes inflammatory demyelination of peripheral nerves. As the most common cause of acute flaccid paralysis, its global annual incidence is 1-4 cases per 100,000 peopl...

Association of EIF2AK3 Variants with Neurocognitive Impairment in People Living with HIV

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
EIF2AK3   single nucleotide variants   HIV   neurocognitive impairment   stress response   genetic variation  

Research Report on the Association between Gene Variants and Neurocognitive Impairment in HIV Patients Over the past few decades, antiretroviral therapy (ART) has greatly improved the health of people infected with human immunodeficiency virus (HIV). However, even with effective viral suppression and partial immune system recovery, up to 50% of Peo...

Potential Role of BMAL1 in Lipopolysaccharide-Induced Depression-Like Behavior and Its Associated "Inflammatory Storm"

Medicine, Infectious Diseases, Basic Medical Sciences, Psychiatry, Neurology, Life Sciences, Immunology,
depression   circadian rhythms   neuroinflammation   synaptic plasticity  

The Role of BMAL1 in LPS-Induced Depressive Behavior and Related “Inflammatory Storm” Introduction According to the 2019 Global Burden of Disease Study, mental disorders are listed as one of the top 10 causes of global burden, with depression being a major contributor. Over 350 million people worldwide suffer from depression, making it the most com...

Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophil   citrullination   CKMT1   intestinal epithelial cells   inflammatory bowel disease   intestinal inflammation   apoptosis  

In recent years, increasing evidence from research on Inflammatory Bowel Disease (IBD) has shown that neutrophils play a crucial role in the occurrence and development of intestinal inflammation. IBD includes Crohn’s Disease (CD) and Ulcerative Colitis (UC), and while its pathogenesis is not yet fully understood, abnormal immune responses are clear...