Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophil   citrullination   CKMT1   intestinal epithelial cells   inflammatory bowel disease   intestinal inflammation   apoptosis  

In recent years, increasing evidence from research on Inflammatory Bowel Disease (IBD) has shown that neutrophils play a crucial role in the occurrence and development of intestinal inflammation. IBD includes Crohn’s Disease (CD) and Ulcerative Colitis (UC), and while its pathogenesis is not yet fully understood, abnormal immune responses are clear...

Mechanistic Study on SENP6 Regulation of IFN-I Signaling Pathway and Antiviral Activity

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Cell Biology, Biochemistry, Immunology,
SENP6   Sumoylation   USP8   IFNAR2   Antiviral Activity  

Academic Background and Research Question In antiviral efficacy research, type I interferon (IFN-I) has been widely used clinically due to its broad-spectrum antiviral properties. However, the specific signaling mechanism and regulatory modes of IFN-I remain complex and not fully elucidated. In light of this, experts have begun to pay attention to ...

GITR Exacerbates Lysophosphatidylcholine-induced Macrophage Pyroptosis in Sepsis via Posttranslational Regulation of NLRP3

Medicine, Infectious Diseases, Rheumatology and Immunology, Life Sciences, Immunology,
GITR   Macrophage   NLRP3 Inflammasome   Sepsis   Posttranslational Modification  

Research Background Sepsis is a life-threatening organ dysfunction syndrome caused by the body’s abnormal response to microbial infection. It has high morbidity and mortality, mainly due to excessive inflammatory response and metabolic disorders. Studies have shown that myeloid cells (such as monocytes and macrophages) play a key role in the pathog...

Neutrophils Disrupt B-1a Cell Homeostasis by Targeting Siglec-G to Exacerbate Sepsis

Medicine, Infectious Diseases, Rheumatology and Immunology, Medical Laboratory Science, Life Sciences, Immunology,
Neutrophils   B-1a Cells   Siglec-G   Sepsis   Immune Regulation  

Research Report: Neutrophils Disrupt B-1a Cell Homeostasis by Targeting Siglec-G, Exacerbating Sepsis Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. The immune system dysfunction accompanying sepsis is primarily triggered by pathogen-associated molecular patterns (PAMPs) and damage-a...

Integrating Single-Nucleus RNA Sequencing and Spatial Transcriptomics to Elucidate a Specialized Subpopulation of Astrocytes, Microglia, and Vascular Cells in a Mouse Model of Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
sepsis   sepsis-associated encephalopathy   single-nucleus RNA sequencing   spatial transcriptomics   ANXA1   glial cell response   cellular localization  

Study on Mouse Sepsis-Associated Encephalopathy Based on Single Cell and Spatial Transcriptomics Background Organ dysfunction leading to death in sepsis is related to an imbalance in the host’s response to infection, and it has a high global mortality rate. Recent studies have shown that sepsis can cause brain dysfunction, known as sepsis-associate...

Herpes Simplex Virus 1 Accelerates the Progression of Alzheimer’s Disease by Modulating Microglial Phagocytosis and Activating NLRP3 Pathway

Medicine, Infectious Diseases, Neurology, Life Sciences, Biochemistry, Immunology, Microbiology,
Herpes Simplex Virus   Alzheimer's Disease   Microglia   NLRP3 Pathway   β-Amyloid   Neuroinflammation  

HSV-1 Infection Accelerates the Progression of Alzheimer’s Disease: Through the Regulation of Microglial Phagocytosis and Activation of the NLRP3 Pathway Research Background With the intensification of global aging, Alzheimer’s Disease (AD) has become a neurodegenerative disease affecting millions of people. In recent years, an increasing number of...