A PRM Mutation that Attenuates Dengue Virus Replication in Human Cells Enhances Midgut Infection in Mosquitoes

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Immunology, Microbiology,
Dengue Virus   PRM Mutation   Virus Replication   Mosquito Infection   1970s   South Pacific   Epidemiology  

Dengue Virus Research: Impact of Genetic Mutations on Virus Transmission and Discoveries Introduction This study was conducted by Allyson N. X. Choi et al. and published in Science Translational Medicine on July 31, 2024. The research aims to reveal the impact of genetic changes in dengue virus on its transmission ability and disease outbreaks duri...

A Self-Amplifying RNA Vaccine Prevents Enterovirus D68 Infection and Disease in Preclinical Models

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Bioengineering, Immunology, Microbiology,
RNA vaccine   Enterovirus D68   nonenveloped virus   antibody responses   vaccine platform   antigenic diversity   preventive vaccine  

A Study on Self-Amplifying RNA Vaccine for Prevention of Enterovirus D68 Infection and Disease in Clinical Models 1. Background In recent years, rapid response to emerging infectious diseases and vaccine development have received much attention. Particularly, the emergence of the novel coronavirus (SARS-CoV-2) has led to rapid advancement in RNA va...

In Vivo Bruton's Tyrosine Kinase Inhibition Attenuates Alcohol-Associated Liver Disease by Regulating CD84-Mediated Granulopoiesis

Medicine, Infectious Diseases, Hepatobiliary System, Gastroenterology, Hematology, Life Sciences, Biochemistry, Immunology,
Bruton's Tyrosine Kinase   Alcohol-Associated Liver Disease   Granulopoiesis   Neutrophils   Liver Damage   Therapeutic Target  

Research Background Severe alcoholic hepatitis (ALD) is a fatal form of alcohol-associated liver disease (AALD). The course of ALD is usually accompanied by neutrophil infiltration in the liver, which significantly affects the severity of the condition. However, the specific effects of alcohol on neutrophil function remain unclear. Based on this, i...

Integrated Single-Cell Multiomic Analysis Reveals Novel Regulators of HIV Latency Reversal

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Genetics,
HIV latency reversal   primary CD4+ T cell   single-cell multiomics   HIV-regulating factor   machine learning  

Comprehensive Single-Cell Multi-Omics Study on HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation This paper, titled “Integrated single-cell multiomic analysis of HIV latency reversal reveals novel regulators of viral reactivation,” was jointly completed by Manickam Ashokkumar, Wenwen Mei, and several other researchers from institu...

Molecular Evolution of Protein Sequences and Codon Usage in Monkeypox Viruses

Medicine, Infectious Diseases, Life Sciences, Cell Biology, Biochemistry, Genetics, Microbiology,
mpox virus   positive selection   opg027   accelerated evolution   codon usage bias  

Molecular Evolution of Monkeypox Virus Protein Sequences and Codon Usage Research Background The 2022 Monkeypox virus (MPXV) outbreak has caused significant global public health concern. However, the evolutionary mechanisms of MPXV remain not fully understood. MPXV is a linear double-stranded DNA virus belonging to the family Poxviridae, subfamily ...

Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii

Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
Toxoplasma gondii   lactylation   protein post-translational modification   metabolism   Chip-seq  

A Study on Protein Lactylation and Metabolic Regulation Reveals New Areas of Toxoplasma gondii Biology Background: Toxoplasma gondii is a globally distributed protozoan parasite that infects over 30% of the world’s population. It causes toxoplasmosis, a widespread zoonotic disease. The parasite has a complex life cycle, including sexual and asexual...