Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Pharmacy, Life Sciences, Biochemistry, Microbiology,
Caseinolytic Protease P   Antistaphylococcal Agents   ZG297   MRSA   Structure-Guided Design   Selective Agonists   Antibiotics  

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents Academic Background Staphylococcus aureus is a common Gram-positive pathogen that can cause various human infections, including skin and soft tissue infections. With the widespread dissemination of methicillin-resistant Staphylococcus aureus (MRS...

Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy

Medicine, Infectious Diseases, Neurology, Medical Imaging, Life Sciences, Biochemistry, Immunology,
multiple sclerosis   anti-CD20   B-cell depletion   disease activity   long-term therapy   adverse events   immunotherapy  

Long-term Intravenous Anti-CD20 Antibody Therapy Assessment in a French Multiple Sclerosis Cohort Background and Research Motivation Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system, leading to varying degrees of physical and cognitive impairment. Recent Phase II and III clinical trials of...

Neuroprotection with Glyceryl Trinitrate Post-Endovascular Therapy in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial

Medicine, Infectious Diseases, Basic Medical Sciences, Emergency Medicine, Neurology, Cardiovascular System, Life Sciences, Biochemistry,
acute ischemic stroke   glyceryl trinitrate   endovascular therapy   neuroprotection   randomized controlled trial  

Overview of Nitroglycerin-Based Neuroprotection in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial Review Background and Research Objectives Acute ischemic stroke (AIS) is one of the leading global causes of disability and death. Despite the significant improvement in vascular recanalization rates and patient outcomes achieved with moder...

Targeting SNRNP200-Induced Splicing Dysregulation as an Immunotherapy Opportunity for Glycolytic Triple-Negative Breast Cancer

Medicine, Infectious Diseases, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
triple-negative breast cancer   SNRNP200   glycolysis   metabolic dysregulation   immunotherapy  

Targeting SNRNP200-Induced Splicing Dysregulation: A New Strategy for Immunotherapy in Glycolytic Triple-Negative Breast Cancer Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, characterized by extremely high recurrence and mortality rates. Despite significant recent advances in research on TNBC subty...

Bacterial Toxins Induce Non-Canonical Migracytosis to Aggravate Acute Inflammation

Medicine, Infectious Diseases, Emergency Medicine, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
bacterial toxins   migracytosis   acute inflammation   C. difficile   small GTPase  

Report on the Study of Bacterial Toxins Inducing Non-Canonical Migracytosis and Aggravating Acute Inflammation Background and Research Objectives In recent years, the discovery of migrasomes, a new type of membrane structure, has gained significant attention in the scientific community for its role in cell migration and various biological functions...

Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic B Cell Pyroptosis upon Viral Infection

Medicine, Infectious Diseases, Endocrinology, Life Sciences, Cell Biology, Biochemistry, Immunology,
vascularized macrophage   islet organoids   B cell pyroptosis   viral infection   immune-mediated  

Background Since the outbreak of the COVID-19 pandemic, SARS-CoV-2 infection has not only affected the respiratory system but has also been closely related to metabolic diseases such as diabetes. Clinical observations have found occurrences of new-onset diabetes and worsening of existing diabetes among COVID-19 patients, particularly with an increa...