Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii

Medicine, Infectious Diseases, Life Sciences, Biochemistry, Microbiology,
Toxoplasma gondii   lactylation   protein post-translational modification   metabolism   Chip-seq  

A Study on Protein Lactylation and Metabolic Regulation Reveals New Areas of Toxoplasma gondii Biology Background: Toxoplasma gondii is a globally distributed protozoan parasite that infects over 30% of the world’s population. It causes toxoplasmosis, a widespread zoonotic disease. The parasite has a complex life cycle, including sexual and asexual...

Novel Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction

Medicine, Infectious Diseases, Hepatobiliary System, Medical Laboratory Science, Life Sciences, Biochemistry, Genetics,
multi-omics   omics technology   sepsis-associated liver dysfunction   single omics   time-dependent integration  

Time-Dependent Multi-Omics Integration in Sepsis-Associated Liver Dysfunction Introduction Sepsis, especially severe cases, causes multiple organ dysfunction due to systemic infection, resulting in up to 5 million deaths globally each year. Traditionally, Sepsis-Associated Liver Dysfunction (SALD) was considered a condition accompanied by jaundice ...

TH17 Cell-Intrinsic Glutathione/Mitochondrial-IL-22 Axis Protects Against Intestinal Inflammation

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Th17 cells   glutathione   mitochondria   IL-22   intestinal inflammation   ROS   gut barrier  

Intrinsic Glutathione/Mitochondrial-IL-22 Axis in TH17 Cells and Its Protective Mechanism Against Intestinal Inflammation Background Introduction A large amount of reactive oxygen species (ROS) is generated in the intestine, and the role of T-cell antioxidant mechanisms in maintaining intestinal homeostasis remains unclear. This paper studies the i...

Sex Differences in the Risk of Stroke Associated with Traditional and Non-Traditional Factors in a US Cohort of People with HIV Infection

Medicine, Infectious Diseases, Neurology, Cardiovascular System,
HIV   stroke   sex differences   cardiovascular risk   lifestyle factors   HIV viremia  

Study on Gender Differences and Stroke Risk Among HIV-Infected Individuals Background Individuals with HIV infection may face a higher risk of stroke, particularly women. However, understanding of whether the influence of various factors on cerebrovascular risk in this population differs by gender and whether these differences contribute to variati...

CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
CD137L   microglia   inflammation   anxiety   cognition   TKS-1  

Background Introduction Sepsis is a life-threatening multiple organ dysfunction syndrome caused by uncontrolled infection in the host, and is one of the leading causes of death in intensive care units. It is reported that there are approximately 189 adult sepsis hospitalization cases per 100,000 person-years, with a mortality rate of 26.7%. Sepsis-...

Increased IL-6 Levels and the Upregulation of Iron Regulatory Biomarkers Contribute to the Progression of Japanese Encephalitis Virus Infection's Pathogenesis

Medicine, Infectious Diseases, Neurology, Hematology, Life Sciences, Cell Biology, Immunology,
Japanese encephalitis virus infection   hepcidin   transferrin   transferrin receptors   IL-6  

Elevated IL-6 Levels and Upregulation of Iron-Regulatory Biomarkers Promote Japanese Encephalitis Virus Infection In this research paper, the authors explore changes in inflammatory response and iron-regulatory biomarkers during Japanese Encephalitis Virus (JEV) infection. A comprehensive analysis of iron-regulatory biomarkers and inflammatory resp...