Development and Validation of a Proteomic Signature of Healthspan

1. Academic Background: From Lifespan Extension to the Enhancement of Healthspan With the improvement of global medical and socioeconomic standards since the 20th century, overall human lifespan has significantly increased, especially in developing countries. However, healthspan—the number of years an individual lives in a state of complete health,...

High-Throughput Metabolomic Profiling of Skin Lesions: Comparative Study of Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma, and Normal Skin via E-Biopsy Sampling

Academic Background Cutaneous Squamous Cell Carcinoma (CSCC) and Basal Cell Carcinoma (BCC) are among the most common types of skin cancer globally. Although the mortality rates of these cancers are relatively low, their incidence has been increasing year by year, significantly impacting patients’ quality of life and potentially leading to prematur...

Predictive Model for Daily Risk Alerts in Sepsis Patients in the ICU: Visualization and Clinical Analysis of Risk Indicators

Sepsis is a systemic inflammatory response syndrome triggered by infection, often leading to multiple organ failure and high mortality rates. Although modern medical technology has made significant progress in the treatment of sepsis, some patients still die due to the rapid deterioration of their condition. Therefore, accurately predicting the mor...

Impact of Rapid ICU-Based Syndromic PCR on Antibiotic Stewardship and Clinical Outcomes in Hospital-Acquired and Ventilator-Associated Pneumonia

INHALE WP3 Study - The Impact of Rapid PCR on ICU Antibiotic Stewardship and Clinical Outcomes Background Introduction Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are common infections in intensive care unit (ICU) patients, with an incidence rate between 5% to 40%, and are associated with high morbidity and increased...

Proteomic Analysis Reveals Distinct Cerebrospinal Fluid Signatures Across Genetic Frontotemporal Dementia Subtypes

Academic Background Frontotemporal Dementia (FTD) is a group of progressive neurodegenerative diseases characterized primarily by behavioral changes, language impairment, or motor dysfunction. Although the incidence of FTD is lower than that of Alzheimer’s Disease (AD), it remains one of the leading causes of early-onset dementia. The molecular bas...