Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth through Stabilizing BRD2

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Phosphocreatine   Glioblastoma   Epigenetic   BRD2   Growth Promotion  

The research results, completed in collaboration by many scientists including Lishu Chen, Qinghui Qi, and Xiaoqing Jiang, were published in the groundbreaking journal Cancer Discovery. The report detailed how phosphocreatine (PCr) promotes the growth of glioblastoma (GBM) by stabilizing bromodomain-containing protein 2 (BRD2). This discovery provid...

CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma

Medicine, Basic Medical Sciences, Neurology, Oncology, Life Sciences, Biochemistry, Genetics,
CHD2   glioma   pediatric   neuron interactions   histone mutation   epigenetic regulation  

Research Report on the Regulation of Neuron-Glioma Interactions by CHD2 in Pediatric Gliomas Background High-grade gliomas (HGG) are fatal diseases in both adult and pediatric patients. Recent studies have shown that neuronal activity can promote the progression of various high-grade glioma subgroups. However, the epigenetic mechanisms regulating t...

Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank

Information Science, Artificial Intelligence, Medicine, Environmental and Public Health, Psychiatry, Neurology, Clinical Psychology, Life Sciences, Genetics,
suicide attempts   behaviour risk factors   physiological risk factors   UK Biobank   multifactor analysis  

Research Background: Suicide is a global public health challenge, but there is still significant uncertainty regarding the relationship between behavioral and physiological factors and suicide attempts (SA). Previous studies often focus on limited hypothesized factors such as mental illnesses (e.g., depression), personality and psychological traits...

Multiplex Cerebrospinal Fluid Proteomics Identifies Biomarkers for Diagnosis and Prediction of Alzheimer's Disease

Medicine, Medical Laboratory Science, Neurology, Medical Imaging, Life Sciences, Cell Biology,
Alzheimer's Disease   Cerebrospinal Fluid   Proteomics   Biomarkers   Diagnosis   Prediction  

Cerebrospinal Fluid Proteomics Study for Diagnosis and Prediction of Alzheimer’s Disease Background and Research Objectives Alzheimer’s disease (AD) is a neurodegenerative disease that leads to memory loss and cognitive decline, and currently, there is no effective cure globally. Traditionally, the pathological features of AD include β-amyloid (Aβ)...

Gene × Environment Effects and Mediation Involving Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence

Medicine, Environmental and Public Health, Neurology,
adverse childhood events   mood disorders   anxiety disorders   substance dependence   gene-environment interaction   mediation   psychopathology  

Study on the Genetic and Environmental Effects of Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence I. Background and Significance Adverse childhood events (ACE) often have profound effects on an individual’s mental health and substance dependence. Previous studies have shown a close relationship between ACE and mood an...

Decision Uncertainty as a Context for Motor Memory

Medicine, Neurology, Sports Medicine, Life Sciences,
decision uncertainty   motor memory   perceptual decision-making   motor learning   contextual cues  

Decision Uncertainty as a Contextual Cue for Motor Memory Background In a penalty shootout during a soccer match, players may face two distinctly different decision-making scenarios. For example, a player may decisively kick the ball to the right corner after seeing the goalkeeper move to the other side, or he may kick the same way without being ce...