Amyloid-Associated Hyperconnectivity Drives Tau Spread Across Connected Brain Regions in Alzheimer’s Disease

Medicine, Neurology,
Alzheimer's disease   tau spread   amyloid   neuronal hyperconnectivity   brain regions   neurodegeneration   functional connectivity  

Amyloid-Associated Hyperconnectivity Drives Tau Spread in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and the abnormal aggregation and spread of tau protein in the brain. The traditional “amyloid cascade hypothesis” posits that...

Early-Onset Sleep Alterations Found in Patients with Amyotrophic Lateral Sclerosis Are Ameliorated by Orexin Antagonist in Mouse Models

Medicine, Neurology,
Amyotrophic Lateral Sclerosis   Sleep Alterations   Orexin Antagonist   Mouse Models   Neurodegenerative Diseases   Cognitive Function   Hypothalamic Signaling  

Mechanisms and Therapeutic Exploration of Early Sleep Abnormalities in Patients with Amyotrophic Lateral Sclerosis Academic Background Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by the degeneration of motor neurons, leading to progressive muscle weakness and respiratory failure. Although the primary symptoms ...

Zinc for GNAO1 Encephalopathy: Preclinical Profiling and a Clinical Case

Medicine, Neurology, Life Sciences, Biochemistry,
GNAO1 encephalopathy   zinc treatment   preclinical research   clinical case   neurodevelopmental disorders  

GNAO1 (G protein alpha subunit O1) gene mutations are considered one of the primary causes of severe pediatric encephalopathy. This encephalopathy typically manifests as epilepsy, movement disorders, developmental delay, and intellectual disability, with limited effectiveness of current treatments. The GαO protein encoded by the GNAO1 gene is a key...

Contextual Neural Dynamics during Time Perception in the Primate Ventral Premotor Cortex

Medicine, Neurology, Life Sciences, Cell Biology, Biophysics,
time perception   ventral premotor cortex   neuronal responses   task-dependence   time intervals  

Neural Dynamics of Time Perception in the Ventral Premotor Cortex Academic Background Time perception is one of the central questions in neuroscience, particularly how the brain encodes time information as cognitive demands change. Time can be categorized as “long” or “short,” or it can be precisely represented as continuous intervals. The ventral ...

Active Vision in Freely Moving Marmosets Using Head-Mounted Eye Tracking

Medicine, Neurology, Ophthalmology, Life Sciences, Bioengineering,
vision   marmosets   eye-tracking   head-mounted devices   natural behavior   vestibulo-ocular reflex   gaze stabilization  

Study of Visual Behavior in Freely Moving Primates: Development and Application of an Innovative Eye-Tracking System Academic Background The visual system is one of the most extensively studied areas within the primate nervous system, particularly concerning the mechanisms of visual pathways in the cerebral cortex. However, current research on how ...

Evidence for Domain-General Arousal from Semantic and Neuroimaging Meta-Analyses Reconciles Opposing Views on Arousal

Medicine, Anesthesiology, Neurology, Life Sciences, Biophysics,
arousal   semantic analysis   neuroimaging   meta-analysis   natural language processing  

Neuroscientific Research Report on “Domain-General Arousal” Academic Background Arousal is a core concept in neuroscience, referring to fluctuations in brain and body states that underpin motivated behavior. Despite the widespread use of the term “arousal,” its definition has remained ambiguous, with differing interpretations in various textbooks. ...